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    ganaba glucosidase II alpha subunit a [ Danio rerio (zebrafish) ]

    Gene ID: 100126019, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ganabaprovided by ZNC
    Official Full Name
    glucosidase II alpha subunit aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070928-36
    See related
    Ensembl:ENSDARG00000076888 AllianceGenome:ZFIN:ZDB-GENE-070928-36
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171967
    Summary
    Predicted to enable carbohydrate binding activity and hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to act upstream of or within carbohydrate metabolic process. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ganaba in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (69138749..69180601, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (68368092..68408232, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ankyrin 1, erythrocytic a Neighboring gene microRNA mir-2188 Neighboring gene solute carrier family 25 member 45 Neighboring gene si:ch73-39o22.3 Neighboring gene small nucleolar RNA SNORA57 Neighboring gene methionine adenosyltransferase 2Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC100126019

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327941.1 → NP_001314870.1  uncharacterized protein LOC100126019 precursor

      Status: VALIDATED

      Source sequence(s)
      CU928129, FO704822
      UniProtKB/TrEMBL
      A0A0R4IPC5, A0A8M1P9L2, B3DIZ3, F1QKH3
      Related
      ENSDARP00000136229.2, ENSDART00000160753.2
      Conserved Domains (3) summary
      cd06603
      Location:358 → 824
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:229 → 358
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:339 → 783
      Glyco_hydro_31; Glycosyl hydrolases family 31

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      69138749..69180601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302024.3 → XP_009300299.1  uncharacterized protein LOC100126019 isoform X2

      UniProtKB/TrEMBL
      A0A8M3BA22
      Conserved Domains (3) summary
      cd06603
      Location:380 → 846
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:251 → 380
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:361 → 805
      Glyco_hydro_31; Glycosyl hydrolases family 31

    2. XM_021475975.2 → XP_021331650.1  uncharacterized protein LOC100126019 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QDG6
      Conserved Domains (2) summary
      cd06603
      Location:380 → 846
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:251 → 380
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105699.1: Suppressed sequence

      Description
      NM_001105699.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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