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    dab2ipb DAB2 interacting protein b [ Danio rerio (zebrafish) ]

    Gene ID: 558237, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dab2ipbprovided by ZNC
    Official Full Name
    DAB2 interacting protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2449
    See related
    Ensembl:ENSDARG00000075110 AllianceGenome:ZFIN:ZDB-GENE-030131-2449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dab2ip; wu:fc08b07; wu:fk62h05
    Summary
    Predicted to enable GTPase activator activity. Human ortholog(s) of this gene implicated in artery disease (multiple); lung cancer; prostate cancer; and stomach cancer. Orthologous to human DAB2IP (DAB2 interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See dab2ipb in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (33678549..33886530, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (33078312..33286372, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-34e4.1 Neighboring gene tubulin tyrosine ligase-like family, member 11 Neighboring gene si:dkeyp-72a4.1 Neighboring gene uncharacterized LOC137495605 Neighboring gene zgc:63972

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An optimized two-finger archive for ZFN-mediated gene targeting. Gupta A, et al. Nat Methods, 2012 Jun. PMID 22543349, Free PMC Article
    2. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
    3. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Zhang P, et al. Cell Rep, 2014 Mar 27. PMID 24613356
    4. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article
    5. Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Webb KJ, et al. Genome Biol, 2009. PMID 19646228, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DAB2 interacting protein b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122857.2 → NP_001116329.1  DAB2 interacting protein b

      Status: VALIDATED

      Source sequence(s)
      BX005265, BX005445
      UniProtKB/TrEMBL
      A0A8M1NFZ4, F1RAN5
      Related
      ENSDARP00000101195.3, ENSDART00000110645.4
      Conserved Domains (6) summary
      cd04013
      Location:202 → 341
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:332 → 655
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:328 → 656
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:645 → 1139
      DUF3498; Domain of unknown function (DUF3498)
      pfam13863
      Location:1009 → 1118
      DUF4200; Domain of unknown function (DUF4200)
      cl17171
      Location:79 → 260
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      33678549..33886530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301511.4 → XP_009299786.1  DAB2 interacting protein b isoform X2

      UniProtKB/TrEMBL
      A0A0R4INY5, A0A8M3ASC9
      Related
      ENSDARP00000137041.2, ENSDART00000159058.2
      Conserved Domains (6) summary
      cd04013
      Location:174 → 313
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:304 → 627
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:300 → 628
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:617 → 1113
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:989 → 1123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:51 → 232
      PH-like; Pleckstrin homology-like domain

    2. XM_005171881.5 → XP_005171938.1  DAB2 interacting protein b isoform X3

      See identical proteins and their annotated locations for XP_005171938.1

      UniProtKB/TrEMBL
      A5PF29
      Conserved Domains (6) summary
      cd04013
      Location:137 → 276
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:267 → 590
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:263 → 591
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:580 → 1076
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:952 → 1086
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:14 → 195
      PH-like; Pleckstrin homology-like domain

    3. XM_005171880.5 → XP_005171937.1  DAB2 interacting protein b isoform X1

      See identical proteins and their annotated locations for XP_005171937.1

      UniProtKB/TrEMBL
      A5PF31, A5PMB2
      Conserved Domains (6) summary
      cd04013
      Location:202 → 341
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:332 → 655
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:328 → 656
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:645 → 1141
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1017 → 1151
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:79 → 260
      PH-like; Pleckstrin homology-like domain

    4. XM_068221215.1 → XP_068077316.1  DAB2 interacting protein b isoform X4

    5. XM_005171883.5 → XP_005171940.1  DAB2 interacting protein b isoform X5

      See identical proteins and their annotated locations for XP_005171940.1

      UniProtKB/TrEMBL
      A5PF30
      Related
      ENSDARP00000121633.1, ENSDART00000133504.2
      Conserved Domains (6) summary
      cd04013
      Location:79 → 218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209 → 532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:205 → 533
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:522 → 1018
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:894 → 1028
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:1 → 137
      PH-like; Pleckstrin homology-like domain

    6. XM_005171884.5 → XP_005171941.1  DAB2 interacting protein b isoform X5

      See identical proteins and their annotated locations for XP_005171941.1

      UniProtKB/TrEMBL
      A5PF30
      Conserved Domains (6) summary
      cd04013
      Location:79 → 218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209 → 532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:205 → 533
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:522 → 1018
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:894 → 1028
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:1 → 137
      PH-like; Pleckstrin homology-like domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394588.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      372478..516202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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