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    myo3a myosin IIIA [ Danio rerio (zebrafish) ]

    Gene ID: 402814, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo3aprovided by ZNC
    Official Full Name
    myosin IIIAprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041026-4
    See related
    Ensembl:ENSDARG00000010186 AllianceGenome:ZFIN:ZDB-GENE-041026-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable microfilament motor activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of filopodium assembly; regulation of actin filament length; and sensory perception of sound. Predicted to act upstream of or within protein phosphorylation and visual perception. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Is expressed in axis; notochord; photoreceptor inner segment layer; polster; and retina. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (myosin IIIA). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See myo3a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (6161266..6294559, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (6131938..6231004, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene NELL (neural EGFL like) family member 3 Neighboring gene glutamate decarboxylase 2 Neighboring gene uncharacterized LOC137489209 Neighboring gene uncharacterized LOC108181524 Neighboring gene zgc:174877

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus. Dosé AC, et al. Mol Biol Cell, 2003 Mar. PMID 12631723, Free PMC Article
    2. Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium. Lin-Jones J, et al. J Comp Neurol, 2009 Mar 10. PMID 19137585, Free PMC Article
    3. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    4. Genetic control of cellular morphogenesis in Müller glia. Charlton-Perkins M, et al. Glia, 2019 Jul. PMID 30924555, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that myo3a is localized in actin-rich ellipsoids of fish cones.
      Title: Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin filament length IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in filopodium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stereocilium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-IIIa
    NP_001349341.1
    NP_991142.2
    XP_068073147.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362412.1 → NP_001349341.1  myosin-IIIa isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BX530066
      UniProtKB/TrEMBL
      Q90XG6
      Related
      ENSDARP00000027033.7, ENSDART00000006636.8
      Conserved Domains (2) summary
      cd01379
      Location:352 → 1079
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:2 → 287
      PKc_like; Protein Kinases, catalytic domain

    2. NM_205579.2 → NP_991142.2  myosin-IIIa isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX530066
      UniProtKB/TrEMBL
      Q90XG6
      Related
      ENSDARP00000113364.1, ENSDART00000136041.2
      Conserved Domains (2) summary
      cd01379
      Location:364 → 1091
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:2 → 287
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      6161266..6294559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217046.1 → XP_068073147.1  myosin-IIIa isoform X1

      UniProtKB/TrEMBL
      Q90XG6
    Nucleotide Protein Strain
    Heading Accession and Version

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