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    acsf2 acyl-CoA synthetase family member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 751707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acsf2provided by ZNC
    Official Full Name
    acyl-CoA synthetase family member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-7
    See related
    Ensembl:ENSDARG00000061201 AllianceGenome:ZFIN:ZDB-GENE-060825-7
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7145554; wu:fi49b09; zgc:152887
    Summary
    Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in mitochondrion. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See acsf2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (26497166..26537996, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (26405806..26446636, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:dkey-287g12.6 Neighboring gene armadillo repeat containing 7 Neighboring gene chondroadherin Neighboring gene FA core complex associated protein 100 Neighboring gene transporter associated with antigen processing, subunit type t, teleost specific Neighboring gene solute carrier family 16 member 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
    2. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
    3. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152887

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    medium-chain acyl-CoA ligase ACSF2, mitochondrial
    Names
    acyl-CoA synthetase family member 2, mitochondrial
    NP_001038884.2
    NP_001132910.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045419.2 → NP_001038884.2  medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001038884.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BG737757, BX324231, CF348078, DT069701, EH575812
      UniProtKB/Swiss-Prot
      Q0P4F7
      UniProtKB/TrEMBL
      A0A8M1NJK7, F1R1C0
      Related
      ENSDARP00000081474.4, ENSDART00000087040.6
      Conserved Domains (1) summary
      PRK08315
      Location:53 → 606
      PRK08315; AMP-binding domain protein; Validated

    2. NM_001139438.1 → NP_001132910.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001132910.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BG737757, CF348078, DT069701, EH554699, EH575812
      UniProtKB/Swiss-Prot
      Q0P4F7
      UniProtKB/TrEMBL
      A0A8M1NJK7, F1R1C0
      Related
      ENSDARP00000132854.1, ENSDART00000163931.2
      Conserved Domains (1) summary
      PRK08315
      Location:53 → 606
      PRK08315; AMP-binding domain protein; Validated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      26497166..26537996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P4F7.1 GenPept UniProtKB/Swiss-Prot:Q0P4F7

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