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    atp2a1l ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [ Danio rerio (zebrafish) ]

    Gene ID: 494489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp2a1lprovided by ZNC
    Official Full Name
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041229-2
    See related
    Ensembl:ENSDARG00000035458 AllianceGenome:ZFIN:ZDB-GENE-041229-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7145237; zgc:154094; si:ch211-198p7.3
    Summary
    Predicted to enable P-type calcium transporter activity. Predicted to be involved in calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to act upstream of or within calcium ion transport. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in gill. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See atp2a1l in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (13244415..13261745)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (13206104..13223442)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene pelota mRNA surveillance and ribosome rescue factor Neighboring gene protein phosphatase 1, catalytic subunit, alpha isozyme b Neighboring gene interferon regulatory factor 9 Neighboring gene ER membrane protein complex subunit 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The cardiovascular toxicity induced by high doses of gatifloxacin and ciprofloxacin in zebrafish. Shen R, et al. Environ Pollut, 2019 Nov. PMID 31454568
    2. The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health. Liu HC, et al. Environ Pollut, 2017 Dec. PMID 28803741
    3. Fenobucarb induces heart failure and cerebral hemorrhage in zebrafish. Zhu XY, et al. Aquat Toxicol, 2019 Apr. PMID 30685545
    4. Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos. Duan J, et al. Nanotoxicology, 2016. PMID 26551753
    5. Behavioral and proteomic analysis of stress response in zebrafish (Danio rerio). Magdeldin S, et al. J Proteome Res, 2015 Feb 6. PMID 25398274, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
    Names
    ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 like
    NP_001071001.1
    XP_005156129.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077533.1 → NP_001071001.1  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like

      See identical proteins and their annotated locations for NP_001071001.1

      Status: PROVISIONAL

      Source sequence(s)
      BC125955
      UniProtKB/TrEMBL
      A0A8M1NBJ3, A0JMP4
      Related
      ENSDARP00000096674.2, ENSDART00000105896.5
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 986
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:781 → 984
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:608 → 709
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 525
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      13244415..13261745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156072.5 → XP_005156129.1  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1

      UniProtKB/TrEMBL
      A0A2R8RK22, A0A8M2B2Q3
      Related
      ENSDARP00000146974.1, ENSDART00000186984.1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 986
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:781 → 984
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:608 → 709
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 525
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

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