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    zgc:103482 zgc:103482 [ Danio rerio (zebrafish) ]

    Gene ID: 450001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zgc:103482provided by ZNC
    Official Full Name
    zgc:103482provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-115
    See related
    Ensembl:ENSDARG00000025174 AllianceGenome:ZFIN:ZDB-GENE-041010-115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    habp4
    Summary
    Enables ribosome binding activity and translation elongation factor binding activity. Involved in ribosome hibernation. Predicted to be located in cytoplasmic stress granule and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Is expressed in primordial germ cell. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zgc:103482 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20396891..20402684)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20360222..20366050)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkey-30k6.5 Neighboring gene heat shock protein, alpha-crystallin-related, b9-like Neighboring gene ephrin-A5a Neighboring gene growth arrest and DNA damage-inducible protein GADD45 gamma-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, et al. Nature, 2023 Jan. PMID 36653451, Free PMC Article
    2. A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Zhang R, et al. Adv Sci (Weinh), 2022 Dec. PMID 36257818, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome hibernation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intracellular hyaluronan-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006022.1 → NP_001006022.1  intracellular hyaluronan-binding protein 4

      See identical proteins and their annotated locations for NP_001006022.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083399
      UniProtKB/Swiss-Prot
      B0R085, Q5XJA5
      Related
      ENSDARP00000007173.7, ENSDART00000003299.9
      Conserved Domains (2) summary
      pfam04774
      Location:152 → 253
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:11 → 96
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      20396891..20402684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161172.5 → XP_005161229.1  intracellular hyaluronan-binding protein 4 isoform X1

      UniProtKB/Swiss-Prot
      B0R085, Q5XJA5
      UniProtKB/TrEMBL
      A0A8M2B834
      Conserved Domains (2) summary
      pfam04774
      Location:152 → 254
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:11 → 96
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XJA5.2 GenPept UniProtKB/Swiss-Prot:Q5XJA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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