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    ckmt2a creatine kinase, mitochondrial 2a (sarcomeric) [ Danio rerio (zebrafish) ]

    Gene ID: 327506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ckmt2aprovided by ZNC
    Official Full Name
    creatine kinase, mitochondrial 2a (sarcomeric)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5717
    See related
    Ensembl:ENSDARG00000069615 AllianceGenome:ZFIN:ZDB-GENE-030131-5717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi14g08; zgc:56085; wu:fi14g08
    Summary
    Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in mitochondrion. Is expressed in myotome and retina. Orthologous to human CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ckmt2a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3111590..3130409)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3061647..3079528, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34Ba Neighboring gene Ras protein-specific guanine nucleotide-releasing factor 2a Neighboring gene ubiquitin-conjugating enzyme E2L 3a Neighboring gene hypermethylated in cancer 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Jiao Y, et al. Fish Shellfish Immunol, 2019 Sep. PMID 31195116
    2. Cardiomyocyte heterogeneity during zebrafish development and regeneration. Tsedeke AT, et al. Dev Biol, 2021 Aug. PMID 33857482
    3. Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Guerra A, et al. Elife, 2018 May 15. PMID 29762122, Free PMC Article
    4. A sart1 Zebrafish Mutant Results in Developmental Defects in the Central Nervous System. Henson HE, et al. Cells, 2020 Oct 22. PMID 33105605, Free PMC Article
    5. Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals gender specific responses and additional mechanisms of cell stress. Carneiro M, et al. Ecotoxicol Environ Saf, 2015 Oct. PMID 26046835

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    creatine kinase, mitochondrial 2a (sarcomeric)
    NP_001295537.1
    NP_001295538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308608.2 → NP_001295537.1  creatine kinase, mitochondrial 2a (sarcomeric) isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      EH115450, EH439325, EH461171, EH612110, LO018559
      UniProtKB/TrEMBL
      A0A2R9YJH5, A0A8M1P1Z0
      Related
      ENSDARP00000092223.5, ENSDART00000101449.5
      Conserved Domains (1) summary
      cd00716
      Location:49 → 406
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    2. NM_001308609.2 → NP_001295538.1  creatine kinase, mitochondrial 2a (sarcomeric) isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate internal exon compared to variant 1. The encoded isoform is the same length but differs in amino acid sequence compared to isoform 1.
      Source sequence(s)
      EH115450, EH439325, EH461171, EH612110, LO018559
      UniProtKB/TrEMBL
      A0A0R4IFJ7, A0A8M1P728
      Related
      ENSDARP00000134106.2, ENSDART00000168670.3
      Conserved Domains (1) summary
      cd00716
      Location:49 → 406
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      3111590..3130409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394799.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      11641..29915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199816.1: Suppressed sequence

      Description
      NM_199816.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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