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    ptpn2a protein tyrosine phosphatase non-receptor type 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393438, updated on 9-Dec-2024

    Summary

    Official Symbol
    ptpn2aprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1196
    See related
    Ensembl:ENSDARG00000016481 AllianceGenome:ZFIN:ZDB-GENE-040426-1196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ptpn2; PTP-1B; zgc:63623; hm:zeh1546
    Summary
    Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and protein kinase binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ptpn2a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (10055428..10071874, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (10164526..10180972, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103908901 Neighboring gene centrosomal protein 76 Neighboring gene centrosomal protein 192 Neighboring gene magnesium transporter MRS2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC63623

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 2a
    Names
    protein tyrosine phosphatase 1B
    protein tyrosine phosphatase, non-receptor type 2, a
    NP_956760.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200466.2NP_956760.2  tyrosine-protein phosphatase non-receptor type 2a

      Status: VALIDATED

      Source sequence(s)
      CR388383, CR533572
      UniProtKB/TrEMBL
      A0A8M1PCX4, F1Q8I4
      Related
      ENSDARP00000118955.1, ENSDART00000136168.3
      Conserved Domains (2) summary
      smart00194
      Location:11274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:41274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      10055428..10071874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)