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    tmprss13b transmembrane serine protease 13b [ Danio rerio (zebrafish) ]

    Gene ID: 564693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmprss13bprovided by ZNC
    Official Full Name
    transmembrane serine protease 13bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090309-2
    See related
    Ensembl:ENSDARG00000077573 AllianceGenome:ZFIN:ZDB-GENE-090309-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fk84e06; si:ch211-139a5.12
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Orthologous to human TMPRSS13 (transmembrane serine protease 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tmprss13b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37888095..37900395, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37287942..37300242, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 35b Neighboring gene FXYD domain containing ion transport regulator 2 Neighboring gene transmembrane serine protease 4b Neighboring gene sodium channel, voltage-gated, type IV, beta b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish. Chatzopoulou A, et al. Endocrinology, 2015 May. PMID 25756310
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 13b
    Names
    transmembrane protease, serine 13b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082844.1 → NP_001076313.1  transmembrane protease serine 13b

      Status: VALIDATED

      Source sequence(s)
      BC155349, CK026108, EH437548, EH467943
      UniProtKB/TrEMBL
      A0A8M1NC15, A9JTI2, E7EYC5
      Related
      ENSDARP00000079276.5, ENSDART00000084841.6
      Conserved Domains (3) summary
      smart00020
      Location:236 → 465
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:237 → 468
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl02509
      Location:146 → 229
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      37888095..37900395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165342.4 → XP_005165399.1  transmembrane protease serine 13b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCQ9, A5PF55, A9JTI2
      Related
      ENSDARP00000079274.5, ENSDART00000084839.7
      Conserved Domains (3) summary
      smart00020
      Location:237 → 466
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:238 → 469
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl02509
      Location:147 → 230
      SRCR_2; Scavenger receptor cysteine-rich domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394596.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      52005..64305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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