aagr-2 P-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aagr-2
Official Full Name: P-type domain-containing protein
Primary source: WormBase:WBGene00019895
Locus tag: CELE_R05F9.12
See related: AllianceGenome:WB:WBGene00019895
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables alpha-1,4-glucosidase activity. Involved in glycogen catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency and glycogen storage disease II. Orthologous to several human genes including MGAM (maltase-glucoamylase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aagr-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (4914494..4925248, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R05F9.13 (e-PCR)
- UniSTS:316944

R05F9.12 (e-PCR)
- UniSTS:312054

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-1,4-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,4-glucosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P-type domain-containing protein

NP_494897.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4914494..4925248 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062496.9 → NP_494897.3 P-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494897.3

Status: REVIEWED

UniProtKB/TrEMBL

Q21750, Q23517

Conserved Domains (4) summary

cd00111
Location:17 → 58

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:287 → 687

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:175 → 287

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam16863
Location:69 → 175

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase