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    gst-2 Glutathione S-transferase 2 [ Caenorhabditis elegans ]

    Gene ID: 177884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-2
    Official Full Name
    Glutathione S-transferase 2
    Primary source
    WormBase:WBGene00001750
    Locus tag
    CELE_K08F4.6
    See related
    AllianceGenome:WB:WBGene00001750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Is expressed in head. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (10140330..10142061, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene Glutathione S-transferase 3 Neighboring gene ncRNA Neighboring gene Glutathione S-transferase 4 Neighboring gene Major sperm protein 38

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a stress-responsive Onchocerca volvulus glutathione S-transferase (Ov-GST-3) by RT-PCR differential display. Liebau E, et al. Mol Biochem Parasitol, 2000 Jul. PMID 10960169
    2. Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans. Kamireddy K, et al. Biomed Pharmacother, 2018 Sep. PMID 30021395
    3. Acrylamide-responsive genes in the nematode Caenorhabditis elegans. Hasegawa K, et al. Toxicol Sci, 2008 Feb. PMID 17989133
    4. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860
    5. Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Pauli F, et al. Development, 2006 Jan. PMID 16354718, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Glutathione S-transferase 2
    NP_501847.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10140330..10142061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069446.4 → NP_501847.1  Glutathione S-transferase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16115, Q21356
      Conserved Domains (2) summary
      cd03192
      Location:84 → 187
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:4 → 73
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16115.1

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