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    C16A3.2 protein-tyrosine-phosphatase [ Caenorhabditis elegans ]

    Gene ID: 182649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C16A3.2
    Official Full Name
    protein-tyrosine-phosphatase
    Primary source
    WormBase:WBGene00015807
    Locus tag
    CELE_C16A3.2
    See related
    AllianceGenome:WB:WBGene00015807
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytosol. Orthologous to several human genes including DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C16A3.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (6389833..6390841)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene S1 motif domain-containing protein Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog Neighboring gene putative ornithine aminotransferase, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine-phosphatase
    NP_498399.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6389833..6390841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065998.2 → NP_498399.1  protein-tyrosine-phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TY00
      Conserved Domains (1) summary
      cd00127
      Location:43 → 182
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version

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