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    gst-38 Glutathione transferase [ Caenorhabditis elegans ]

    Gene ID: 185299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-38
    Official Full Name
    Glutathione transferase
    Primary source
    WormBase:WBGene00001786
    Locus tag
    CELE_F35E8.8
    See related
    AllianceGenome:WB:WBGene00001786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Involved in PERK-mediated unfolded protein response and innate immune response. Is expressed in intestine and nervous system. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-38 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (15915162..15916070, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene ShKT domain-containing protein Neighboring gene ShKT domain-containing protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity. Vanduyn N, et al. Toxicol Sci, 2010 Dec. PMID 20855423, Free PMC Article
    2. Organic carbon source in formulated sediments influences life traits and gene expression of Caenorhabditis elegans. Franzen J, et al. Ecotoxicology, 2012 Mar. PMID 22080434
    3. Acrylamide-responsive genes in the nematode Caenorhabditis elegans. Hasegawa K, et al. Toxicol Sci, 2008 Feb. PMID 17989133
    4. Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. Wang C, et al. Environ Pollut, 2019 Mar. PMID 31159140
    5. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response HEP PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    Glutathione transferase
    NP_506983.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15915162..15916070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074582.6 → NP_506983.1  Glutathione transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45451
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 207
      PTZ00057; glutathione s-transferase; Provisional
      cd03192
      Location:85 → 191
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:4 → 75
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    Nucleotide Protein
    Heading Accession and Version

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