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    nhr-221 Nuclear Hormone Receptor family [ Caenorhabditis elegans ]

    Gene ID: 188826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-221
    Official Full Name
    Nuclear Hormone Receptor family
    Primary source
    WormBase:WBGene00020748
    Locus tag
    CELE_T24A6.8
    See related
    AllianceGenome:WB:WBGene00020748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-221 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (3532914..3535360, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Nuclear Hormone Receptor family Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear Hormone Receptor family
    NP_001309664.1
    • Confirmed by transcript evidence
    NP_503987.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3532914..3535360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071586.5 → NP_503987.1  Nuclear Hormone Receptor family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61939
      Conserved Domains (3) summary
      smart00399
      Location:33 → 105
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:209 → 360
      HOLI; Ligand binding domain of hormone receptors
      cl11397
      Location:176 → 238
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. NM_001322529.3 → NP_001309664.1  Nuclear Hormone Receptor family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MB63
      Conserved Domains (3) summary
      smart00399
      Location:1 → 71
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:175 → 326
      HOLI; Ligand binding domain of hormone receptors
      cl11397
      Location:142 → 204
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version

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