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    ncbp-2 Nuclear cap-binding protein subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 184953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncbp-2
    Official Full Name
    Nuclear cap-binding protein subunit 2
    Primary source
    WormBase:WBGene00009141
    Locus tag
    CELE_F26A3.2
    See related
    AllianceGenome:WB:WBGene00009141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA cap binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nuclear envelope and nuclear periphery. Is expressed in germ cell. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncbp-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (7642457..7643328, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Condensin complex subunit capg-1 Neighboring gene ncRNA Neighboring gene Lipid droplet-associated hydrolase Neighboring gene RNA-directed RNA polymerase Neighboring gene RNA-directed RNA polymerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans. Shanley HT, et al. Bioorg Med Chem, 2024 Jan 15. PMID 38134663
    2. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline. Pushpa K, et al. Development, 2013 Mar. PMID 23444359, Free PMC Article
    3. Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis. Lall S, et al. Mol Biol Cell, 2005 Dec. PMID 16207815, Free PMC Article
    4. A modular network model of aging. Xue H, et al. Mol Syst Biol, 2007. PMID 18059442, Free PMC Article
    5. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear cap binding complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear cap-binding protein subunit 2
    NP_001250553.1
    • Confirmed by transcript evidence
    NP_001250554.1
    • Confirmed by transcript evidence
    NP_001370288.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7642457..7643328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383376.2 → NP_001370288.1  Nuclear cap-binding protein subunit 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G3MU41, G3MU42, G3MU43, Q93594
      Conserved Domains (1) summary
      cd12240
      Location:39 → 116
      RRM_NCBP2; RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

    2. NM_001263624.3 → NP_001250553.1  Nuclear cap-binding protein subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93594
      Conserved Domains (2) summary
      COG0724
      Location:1 → 70
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:1 → 49
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001263625.3 → NP_001250554.1  Nuclear cap-binding protein subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93594
      Conserved Domains (1) summary
      cl17169
      Location:1 → 14
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93594.2

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