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    ZK546.2 Leucine-rich repeat-containing protein 57 [ Caenorhabditis elegans ]

    Gene ID: 173855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK546.2
    Official Full Name
    Leucine-rich repeat-containing protein 57
    Primary source
    WormBase:WBGene00022759
    Locus tag
    CELE_ZK546.2
    See related
    AllianceGenome:WB:WBGene00022759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in cytoplasm. Orthologous to human LRRC57 (leucine rich repeat containing 57). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK546.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (4946027..4948070)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 4 Neighboring gene Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein;SURF6 homolog gldi-11 Neighboring gene Peptidase S1 domain-containing protein Neighboring gene Zygote defective protein 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat-containing protein 57
    NP_001380033.1
    • Confirmed by transcript evidence
    NP_740983.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4946027..4948070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170985.5 → NP_740983.2  Leucine-rich repeat-containing protein 57 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740983.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23526, Q23527
      Conserved Domains (4) summary
      cd00116
      Location:208 → 460
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:264 → 286
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:65 → 107
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:308 → 364
      LRR_8; Leucine rich repeat

    2. NM_001393057.1 → NP_001380033.1  Leucine-rich repeat-containing protein 57 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PW8
      Conserved Domains (2) summary
      COG4886
      Location:37 → 209
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:40 → 62
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. NR_151581.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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