lon-3 Cuticle collagen lon-3 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: lon-3
Official Full Name: Cuticle collagen lon-3
Primary source: WormBase:WBGene00003057
Locus tag: CELE_ZK836.1
See related: AllianceGenome:WB:WBGene00003057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of collagen and cuticulin-based cuticle. Involved in body morphogenesis and regulation of growth. Located in annuli extracellular matrix. Is expressed in several structures, including H1L.apa; H1L.appa; H1L.p; cuticle; and hypodermal cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 5. Orthologous to human COLQ (collagen like tail subunit of asymmetric acetylcholinesterase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining body shape.
Title: A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables structural constituent of collagen and cuticulin-based cuticle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of collagen and cuticulin-based cuticle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables structural constituent of cuticle	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in annuli extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in collagen and cuticulin-based cuticle extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen and cuticulin-based cuticle extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info

NP_506061.1

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The following sections contain reference sequences that belong to a specific genome build. Explain