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    unc-2 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180570, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-2
    Official Full Name
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00006742
    Locus tag
    CELE_T02C5.5
    See related
    AllianceGenome:WB:WBGene00006742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable high voltage-gated calcium channel activity. Involved in several processes, including determination of left/right asymmetry in nervous system; negative regulation of transforming growth factor beta receptor signaling pathway; and response to heat. Located in presynaptic active zone membrane. Is expressed in several structures, including body wall musculature; excretory canal; head; neurons; and pharyngeal muscle cell. Used to study migraine. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; developmental and epileptic encephalopathy (multiple); hereditary ataxia (multiple); and migraine (multiple). Orthologous to several human genes including CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    40
    Sequence:
    Chromosome: X; NC_003284.9 (2710920..2763526, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Membrane-associated protein Neighboring gene TNFR-Cys domain-containing protein Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity  
    enables high voltage-gated calcium channel activity  
    enables metal ion binding  
    enables monoatomic ion channel activity  
    enables voltage-gated calcium channel activity  
    enables voltage-gated calcium channel activity PubMed 
    Component Evidence Code Pubs
    located_in membrane  
    part_of monoatomic ion channel complex  
    located_in presynaptic active zone membrane PubMed 
    located_in synapse  
    part_of voltage-gated calcium channel complex  
    part_of voltage-gated calcium channel complex  

    General protein information

    Preferred Names
    EF-hand domain-containing protein
    NP_001335515.1
    • Confirmed by transcript evidence
    NP_001335516.1
    • Confirmed by transcript evidence
    NP_001335560.1
    • Confirmed by transcript evidence
    NP_001335561.1
    • Confirmed by transcript evidence
    NP_001335562.1
    • Confirmed by transcript evidence
    NP_001335563.1
    • Confirmed by transcript evidence
    NP_001335570.1
    • Partially confirmed by transcript evidence
    NP_001335571.1
    • Partially confirmed by transcript evidence
    NP_001335572.1
    • Partially confirmed by transcript evidence
    NP_001335573.1
    • Partially confirmed by transcript evidence
    NP_001355462.1
    • Partially confirmed by transcript evidence
    NP_001355463.1
    • Partially confirmed by transcript evidence
    NP_001355464.1
    • Partially confirmed by transcript evidence
    NP_001355494.1
    • Partially confirmed by transcript evidence
    NP_741732.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2710920..2763526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171638.3 → NP_741732.2  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741732.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86G45, Q8MPY6
      Conserved Domains (3) summary
      pfam00520
      Location:1179 → 1433
      Ion_trans; Ion transport protein
      pfam08763
      Location:1506 → 1582
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1442 → 1495
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    2. NM_001348592.5 → NP_001335571.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYU4
      Conserved Domains (4) summary
      pfam05539
      Location:1885 → 2042
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      pfam00520
      Location:1201 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1604
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1464 → 1517
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    3. NM_001348596.5 → NP_001335516.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPY5
      Conserved Domains (3) summary
      pfam00520
      Location:1045 → 1299
      Ion_trans; Ion transport protein
      pfam08763
      Location:1372 → 1448
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1308 → 1361
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    4. NM_001348594.5 → NP_001335570.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYU0
      Conserved Domains (4) summary
      pfam05539
      Location:1903 → 2060
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      pfam00520
      Location:1201 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1604
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1464 → 1517
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    5. NM_001368494.4 → NP_001355464.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E663
      Conserved Domains (3) summary
      pfam00520
      Location:1323 → 1577
      Ion_trans; Ion transport protein
      pfam08763
      Location:1650 → 1726
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1586 → 1639
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    6. NM_001368495.4 → NP_001355463.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1DR32
      Conserved Domains (3) summary
      pfam00520
      Location:1271 → 1525
      Ion_trans; Ion transport protein
      pfam08763
      Location:1598 → 1674
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1534 → 1587
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    7. NM_001368496.4 → NP_001355462.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E4Z9
      Conserved Domains (3) summary
      pfam00520
      Location:1279 → 1533
      Ion_trans; Ion transport protein
      pfam08763
      Location:1606 → 1682
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1542 → 1595
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    8. NM_001348588.4 → NP_001335561.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYT0
      Conserved Domains (4) summary
      pfam05539
      Location:1820 → 1977
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      pfam00520
      Location:1136 → 1390
      Ion_trans; Ion transport protein
      pfam08763
      Location:1463 → 1539
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1399 → 1452
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    9. NM_001348589.4 → NP_001335563.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYU6
      Conserved Domains (3) summary
      pfam00520
      Location:1136 → 1390
      Ion_trans; Ion transport protein
      pfam08763
      Location:1463 → 1539
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1399 → 1452
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    10. NM_001348590.4 → NP_001335560.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYV5
      Conserved Domains (4) summary
      pfam05539
      Location:1838 → 1995
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      pfam00520
      Location:1136 → 1390
      Ion_trans; Ion transport protein
      pfam08763
      Location:1463 → 1539
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1399 → 1452
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    11. NM_001348591.4 → NP_001335562.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYT1
      Conserved Domains (3) summary
      pfam00520
      Location:1136 → 1390
      Ion_trans; Ion transport protein
      pfam08763
      Location:1463 → 1539
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1399 → 1452
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    12. NM_001348593.4 → NP_001335573.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYT8
      Conserved Domains (3) summary
      pfam00520
      Location:1201 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1604
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1464 → 1517
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    13. NM_001348595.4 → NP_001335572.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYV7
      Conserved Domains (3) summary
      pfam00520
      Location:1201 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1604
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1464 → 1517
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    14. NM_001368497.5 → NP_001355494.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E695
      Conserved Domains (3) summary
      pfam00520
      Location:1137 → 1391
      Ion_trans; Ion transport protein
      pfam08763
      Location:1464 → 1540
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1400 → 1453
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    15. NM_001348597.2 → NP_001335515.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFB0
      Conserved Domains (3) summary
      pfam00520
      Location:1045 → 1299
      Ion_trans; Ion transport protein
      pfam08763
      Location:1372 → 1448
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1308 → 1361
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
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