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    pfd-2 Prefoldin subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 173768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pfd-2
    Official Full Name
    Prefoldin subunit 2
    Primary source
    WormBase:WBGene00019220
    Locus tag
    CELE_H20J04.5
    See related
    AllianceGenome:WB:WBGene00019220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein folding chaperone. Predicted to be involved in protein folding. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pfd-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (4326720..4328284)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 222 Neighboring gene putative U2 small nuclear ribonucleoprotein A' Neighboring gene RNA helicase Neighboring gene Alcohol dehydrogenase transcription factor myb/sant-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans. Lundin VF, et al. Dev Biol, 2008 Jan 1. PMID 18062952
    2. Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components. Tarailo M, et al. Genetics, 2007 Dec. PMID 18073444, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Prefoldin subunit 2
    NP_494764.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4326720..4328284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062363.8 → NP_494764.1  Prefoldin subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494764.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5M2
      Conserved Domains (1) summary
      pfam01920
      Location:18 → 120
      Prefoldin_2; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N5M2.1

    Gene LinkOut

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