hecd-1 E3 ubiquitin-protein ligase;E3 ubiquitin-protein ligase hecd-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hecd-1
Official Full Name: E3 ubiquitin-protein ligase;E3 ubiquitin-protein ligase hecd-1
Primary source: WormBase:WBGene00016405
Locus tag: CELE_C34D4.14
See related: AllianceGenome:WB:WBGene00016405
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including determination of adult lifespan; hemidesmosome assembly; and regulation of Notch signaling pathway. Predicted to be active in nuclear speck. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hecd-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 22

Sequence:: Chromosome: IV; NC_003282.8 (7134346..7144720, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function.
Title: Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function.
hecd-1 acts as a positive modulator of lin-12/Notch activity in a somatic gonad context, -but acts autonomously as a negative modulator of glp-1/Notch activity in the germ line.
Title: hecd-1 modulates notch activity in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34D4.14 (e-PCR)
- UniSTS:308710

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase;E3 ubiquitin-protein ligase hecd-1

NP_001293688.1

Confirmed by transcript evidence

NP_001293689.1

Confirmed by transcript evidence

NP_001293691.1

Confirmed by transcript evidence

NP_001368363.1

Confirmed by transcript evidence

NP_001368364.1

Confirmed by transcript evidence

NP_001368365.1

Confirmed by transcript evidence

NP_001368366.1

Confirmed by transcript evidence

NP_001368367.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7134346..7144720 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380310.2 → NP_001368366.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CL75

Conserved Domains (4) summary

cd00078
Location:2184 → 2611

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1415 → 1472

MIB_HERC2; Mib_herc2

cl23730
Location:1206 → 1328

F5_F8_type_C; F5/8 type C domain
NM_001380311.1 → NP_001368364.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLC0

Conserved Domains (6) summary

PTZ00322
Location:383 → 497

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd00078
Location:2217 → 2644

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1448 → 1505

MIB_HERC2; Mib_herc2

pfam12796
Location:345 → 436

Ank_2; Ankyrin repeats (3 copies)

cl23730
Location:1239 → 1361

F5_F8_type_C; F5/8 type C domain
NM_001380312.2 → NP_001368365.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLA7

Conserved Domains (6) summary

PTZ00322
Location:383 → 497

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd00078
Location:2221 → 2648

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1452 → 1509

MIB_HERC2; Mib_herc2

pfam12796
Location:345 → 436

Ank_2; Ankyrin repeats (3 copies)

cl23730
Location:1243 → 1365

F5_F8_type_C; F5/8 type C domain
NM_001380309.1 → NP_001368367.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIS8

Conserved Domains (4) summary

cd00078
Location:2180 → 2607

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1411 → 1468

MIB_HERC2; Mib_herc2

cl23730
Location:1202 → 1324

F5_F8_type_C; F5/8 type C domain
NM_001380308.2 → NP_001368363.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIS4

Conserved Domains (4) summary

cd00078
Location:2178 → 2605

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1409 → 1466

MIB_HERC2; Mib_herc2

cl23730
Location:1200 → 1322

F5_F8_type_C; F5/8 type C domain
NM_001306760.2 → NP_001293689.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293689.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CL74

Conserved Domains (4) summary

cd00078
Location:2182 → 2609

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1413 → 1470

MIB_HERC2; Mib_herc2

cl23730
Location:1204 → 1326

F5_F8_type_C; F5/8 type C domain
NM_001306762.2 → NP_001293691.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293691.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CJX7

Conserved Domains (6) summary

PTZ00322
Location:383 → 497

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd00078
Location:2215 → 2642

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1446 → 1503

MIB_HERC2; Mib_herc2

pfam12796
Location:345 → 436

Ank_2; Ankyrin repeats (3 copies)

cl23730
Location:1237 → 1359

F5_F8_type_C; F5/8 type C domain
NM_001306759.2 → NP_001293688.1 E3 ubiquitin-protein ligase hecd-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293688.1

Status: REVIEWED

UniProtKB/Swiss-Prot

V6CLA2

Conserved Domains (6) summary

PTZ00322
Location:383 → 497

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd00078
Location:2219 → 2646

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

sd00045
Location:345 → 372

ANK; ANK repeat [structural motif]

pfam06701
Location:1450 → 1507

MIB_HERC2; Mib_herc2

pfam12796
Location:345 → 436

Ank_2; Ankyrin repeats (3 copies)

cl23730
Location:1241 → 1363

F5_F8_type_C; F5/8 type C domain