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    cgt-1 Ceramide glucosyltransferase 1 [ Caenorhabditis elegans ]

    Gene ID: 188169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cgt-1
    Official Full Name
    Ceramide glucosyltransferase 1
    Primary source
    WormBase:WBGene00011517
    Locus tag
    CELE_T06C12.10
    See related
    AllianceGenome:WB:WBGene00011517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide glucosyltransferase activity. Involved in glucosylceramide biosynthetic process; nematode larval development; and regulation of protein localization to basolateral plasma membrane. Predicted to be active in membrane. Is expressed in excretory system; intestine; pharyngeal muscle cell; pharyngeal-intestinal valve; and rectum. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cgt-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (15886719..15888851, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Acyl_transf_3 domain-containing protein;Acyltransferase 3 domain-containing protein Neighboring gene Plasma membrane proteolipid 3 Neighboring gene Movement protein Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan. Arvin CL, et al. MicroPubl Biol, 2023. PMID 37090153, Free PMC Article
    2. Glucosylceramide synthase and glycosphingolipid synthesis. Ichikawa S, et al. Trends Cell Biol, 1998 May. PMID 9695839
    3. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Piulats JM, et al. Clin Cancer Res, 2018 Aug 1. PMID 29618620
    4. Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. Marza E, et al. J Cell Sci, 2009 Mar 15. PMID 19240113, Free PMC Article
    5. Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division. Nomura KH, et al. Glycobiology, 2011 Jun. PMID 21325339

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Animals lacking CGT do not synthesize glycosphingolipids, arrest growth at the first larval stage, and display defects in a subset of cells in their digestive tract.
      Title: Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucosylceramide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein localization to basolateral plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ceramide glucosyltransferase 1
    NP_506971.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15886719..15888851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074570.6 → NP_506971.2  Ceramide glucosyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506971.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18037
      Conserved Domains (2) summary
      TIGR03472
      Location:68 → 446
      HpnI; hopanoid biosynthesis associated glycosyl transferase protein HpnI
      cd02520
      Location:107 → 338
      Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18037.2

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