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    natc-1 Protein MAK10 homolog [ Caenorhabditis elegans ]

    Gene ID: 179228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    natc-1
    Official Full Name
    Protein MAK10 homolog
    Primary source
    WormBase:WBGene00020719
    Locus tag
    CELE_T23B12.4
    See related
    AllianceGenome:WB:WBGene00020719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to peptide alpha-N-acetyltransferase activity. Involved in several processes, including determination of adult lifespan; stress response to cadmium ion; and stress response to copper ion. Located in cytoplasm. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See natc-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (8462359..8465569)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene J domain-containing protein Neighboring gene 28S ribosomal protein S2, mitochondrial Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL4m

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New links between protein N-terminal acetylation, dauer diapause, and the insulin/IGF-1 signaling pathway in Caenorhabditis elegans. Warnhoff K, et al. Worm, 2015 Apr-Jun. PMID 26435887, Free PMC Article
    2. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing. Bruinsma JJ, et al. Genetics, 2008 Jun. PMID 18505880, Free PMC Article
    3. The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. Warnhoff K, et al. PLoS Genet, 2014 Oct. PMID 25330323, Free PMC Article
    4. Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans. Evans KS, et al. PLoS Genet, 2020 Nov. PMID 33175833, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel biological function for Natc-1 as a modulator of stress resistance and dauer formation and define a functionally significant downstream effector of the insulin/IGF-1 signaling pathway.
      Title: The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to paraquat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress response to zinc ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stress response to zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NatC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein MAK10 homolog
    NP_505179.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8462359..8465569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072778.8 → NP_505179.1  Protein MAK10 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17003
      Conserved Domains (3) summary
      pfam04112
      Location:28 → 155
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
      pfam09026
      Location:273 → 317
      CENP-B_dimeris; Centromere protein B dimerization domain
      pfam09184
      Location:222 → 306
      PPP4R2; PPP4R2
    Nucleotide Protein
    Heading Accession and Version

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