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    duox-2 NAD(P)H oxidase (H2O2-forming) [ Caenorhabditis elegans ]

    Gene ID: 186188, updated on 9-Dec-2024

    Summary

    Official Symbol
    duox-2
    Official Full Name
    NAD(P)H oxidase (H2O2-forming)
    Primary source
    WormBase:WBGene00018771
    Locus tag
    CELE_F53G12.3
    See related
    AllianceGenome:WB:WBGene00018771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Predicted to be located in membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to several human genes including DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See duox-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (137845..144565)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Growth-regulating factor;K Homology domain-containing protein Neighboring gene LisH domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Dual oxidase 1 Neighboring gene SSD domain-containing protein

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in post-embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NAD(P)H oxidase (H2O2-forming)
    NP_490684.1
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      137845..144565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058283.1NP_490684.1  NAD(P)H oxidase (H2O2-forming) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01795
      Conserved Domains (5) summary
      cd06186
      Location:12241408
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41596
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      COG5126
      Location:792895
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam01794
      Location:10411182
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03098
      Location:39552
      An_peroxidase; Animal haem peroxidase