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    pst-2 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 [ Caenorhabditis elegans ]

    Gene ID: 175787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pst-2
    Official Full Name
    Adenosine 3'-phospho 5'-phosphosulfate transporter 2
    Primary source
    WormBase:WBGene00018827
    Locus tag
    CELE_F54E7.1
    See related
    AllianceGenome:WB:WBGene00018827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate transport. Located in Golgi cis cisterna membrane and Golgi medial cisterna membrane. Is expressed in hypodermis; intestine; pharyngeal gland cell; and vulva. Orthologous to human SLC35B3 (solute carrier family 35 member B3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pst-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5680433..5682325)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS12 Neighboring gene ncRNA Neighboring gene Calcipressin-like protein Neighboring gene SH3 domain-containing protein Neighboring gene ARF7 effector protein C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans. Dejima K, et al. J Biol Chem, 2010 Aug 6. PMID 20529843, Free PMC Article
    2. An organelle gatekeeper function for Caenorhabditis elegans UNC-16 (JIP3) at the axon initial segment. Edwards SL, et al. Genetics, 2013 May. PMID 23633144, Free PMC Article
    3. The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans. Bhattacharya R, et al. J Cell Sci, 2009 Dec 15. PMID 19920077, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pst-1 and pst-2 play different physiological roles in heparan sulfate modification and development
      Title: Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi medial cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Adenosine 3'-phospho 5'-phosphosulfate transporter 2
    NP_001040855.1
    • Confirmed by transcript evidence
    NP_001040856.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5680433..5682325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047390.4 → NP_001040855.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1W0S3, Q20787
      Conserved Domains (1) summary
      pfam08449
      Location:41 → 332
      UAA; UAA transporter family

    2. NM_001047391.4 → NP_001040856.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20787
      Conserved Domains (1) summary
      pfam08449
      Location:1 → 215
      UAA; UAA transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20787.1

    Gene LinkOut

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