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    set-11 SET domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-11
    Official Full Name
    SET domain-containing protein
    Primary source
    WormBase:WBGene00018023
    Locus tag
    CELE_F34D6.4
    See related
    AllianceGenome:WB:WBGene00018023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3 methyltransferase activity; protein-lysine N-methyltransferase activity; and zinc ion binding activity. Involved in innate immune response. Predicted to be located in chromosome and nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in Kleefstra syndrome; Kleefstra syndrome 1; and idiopathic pulmonary fibrosis. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1) and EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (2690472..2692576, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group F Neighboring gene Nematode Specific Peptide family, group F Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class I Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development. Simonet T, et al. Dev Biol, 2007 Dec 1. PMID 17967446
    2. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, et al. Nature, 2010 Jul 15. PMID 20555324, Free PMC Article
    3. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
    4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
    5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H3 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SET domain-containing protein
    NP_001364763.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2690472..2692576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377732.1 → NP_001364763.1  SET domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17186
      Conserved Domains (2) summary
      smart00468
      Location:21 → 117
      PreSET; N-terminal to some SET domains
      cl40432
      Location:75 → 270
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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