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    tctn-1 Tectonic domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tctn-1
    Official Full Name
    Tectonic domain-containing protein
    Primary source
    WormBase:WBGene00017120
    Locus tag
    CELE_E04A4.6
    See related
    AllianceGenome:WB:WBGene00017120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cilium assembly. Predicted to be located in membrane. Predicted to be active in ciliary transition zone. Is expressed in amphid neurons and phasmid neurons. Human ortholog(s) of this gene implicated in Joubert syndrome 13; Joubert syndrome 18; and orofaciodigital syndrome IV. Orthologous to human TCTN1 (tectonic family member 1) and TCTN3 (tectonic family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tctn-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (4745823..4747832, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z Neighboring gene putative mitochondrial import inner membrane translocase subunit tim-17B.1 Neighboring gene Cytochrome c 2.1 Neighboring gene Large ribosomal subunit protein eL20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. Yee LE, et al. PLoS Genet, 2015 Nov. PMID 26540106, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tectonic domain-containing protein
    NP_500628.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4745823..4747832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068227.4 → NP_500628.2  Tectonic domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500628.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44478
    Nucleotide Protein
    Heading Accession and Version

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