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    elac-2 Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z [ Caenorhabditis elegans ]

    Gene ID: 177241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elac-2
    Official Full Name
    Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z
    Primary source
    WormBase:WBGene00001983
    Locus tag
    CELE_E04A4.4
    See related
    AllianceGenome:WB:WBGene00001983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-tRNA processing endoribonuclease activity. Involved in several processes, including germ cell development; nematode larval development; and positive regulation of vulval development. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Is expressed in germ line. Used to study prostate cancer. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elac-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (4739490..4744267, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene F-box associated domain-containing protein Neighboring gene putative mitochondrial import inner membrane translocase subunit tim-17B.1 Neighboring gene Tectonic domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation. Smith MM, et al. Dev Biol, 2004 Feb 1. PMID 14729485
    2. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Held JP, et al. Elife, 2022 Apr 22. PMID 35451962, Free PMC Article
    3. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article
    4. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. required for hyperproliferation phenotypes seen with mutations in three different genes, suggesting it may be generally required for germline proliferation
      Title: The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    Zinc phosphodiesterase ELAC protein 2 homolog;ribonuclease Z
    NP_001023109.1
    • Partially confirmed by transcript evidence
    NP_001023110.1
    • Confirmed by transcript evidence
    NP_001294339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4739490..4744267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027938.7 → NP_001023109.1  Zinc phosphodiesterase ELAC protein 2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44476, Q688B7
      Conserved Domains (3) summary
      COG1234
      Location:493 → 786
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:494 → 719
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:122 → 304
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. NM_001027939.4 → NP_001023110.1  Zinc phosphodiesterase ELAC protein 2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44476
      Conserved Domains (3) summary
      COG1234
      Location:420 → 713
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:421 → 646
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:49 → 231
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. NM_001307410.3 → NP_001294339.1  ribonuclease Z [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PR60
      Conserved Domains (1) summary
      cl23716
      Location:3 → 38
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44476.2

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