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    uso-1 Uso1_p115_head domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uso-1
    Official Full Name
    Uso1_p115_head domain-containing protein
    Primary source
    WormBase:WBGene00010713
    Locus tag
    CELE_K09B11.9
    See related
    AllianceGenome:WB:WBGene00010713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in several processes, including Golgi vesicle transport; intracellular protein transport; and transcytosis. Predicted to be located in Golgi membrane. Predicted to be active in ER to Golgi transport vesicle membrane; Golgi stack; and endoplasmic reticulum. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uso-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (13445390..13454798, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a functional domain within the p115 tethering factor that is required for Golgi ribbon assembly and membrane trafficking. Grabski R, et al. J Cell Sci, 2012 Apr 15. PMID 22328511, Free PMC Article
    2. MitoSNARE Assembly and Disassembly Factors Regulate Basal Autophagy and Aging in C. elegans. Gkikas I, et al. Int J Mol Sci, 2023 Feb 20. PMID 36835643, Free PMC Article
    3. Predicting aging/longevity-related genes in the nematode Caenorhabditis elegans. Witten TM, et al. Chem Biodivers, 2007 Nov. PMID 18027377
    4. Conserved genes act as modifiers of invertebrate SMN loss of function defects. Dimitriadi M, et al. PLoS Genet, 2010 Oct 28. PMID 21124729, Free PMC Article
    5. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CC4 doamin is required for p115 for Golgi ribbon formation and cargo trafficking.
      Title: Identification of a functional domain within the p115 tethering factor that is required for Golgi ribbon assembly and membrane trafficking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uso1_p115_head domain-containing protein
    NP_001040973.1
    • Confirmed by transcript evidence
    NP_001040974.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13445390..13454798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047509.2 → NP_001040974.1  Uso1_p115_head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2EEM5
      Conserved Domains (2) summary
      pfam04869
      Location:349 → 630
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam04871
      Location:750 → 872
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

    2. NM_001047508.3 → NP_001040973.1  Uso1_p115_head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGG0
      Conserved Domains (2) summary
      pfam04869
      Location:415 → 696
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam04871
      Location:816 → 938
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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