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    rabi-1 GDP/GTP exchange factor Sec2 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186226, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rabi-1
    Official Full Name
    GDP/GTP exchange factor Sec2 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00010045
    Locus tag
    CELE_F54C9.11
    See related
    AllianceGenome:WB:WBGene00010045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Is expressed in hypodermis; vulA; vulB1; vulB2; and vulval muscle. Orthologous to human RAB3IP (RAB3A interacting protein) and RAB3IL1 (RAB3A interacting protein like 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See rabi-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8583034..8585086, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Pumilio domain-containing protein 5 Neighboring gene Protein KRI1 homolog Neighboring gene ADP-ribosylation factor-like protein 1 Neighboring gene Transcription factor aptf-4 Neighboring gene Transcription factor AP-2 C-terminal domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDP/GTP exchange factor Sec2 N-terminal domain-containing protein
    NP_495817.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8583034..8585086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063416.5 → NP_495817.3  GDP/GTP exchange factor Sec2 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495817.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20759
      Conserved Domains (1) summary
      pfam06428
      Location:61 → 133
      Sec2p; GDP/GTP exchange factor Sec2p
    Nucleotide Protein
    Heading Accession and Version

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