hmbx-1 Homeobox-containing protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmbx-1
Official Full Name: Homeobox-containing protein 1
Primary source: WormBase:WBGene00018786
Locus tag: CELE_F54A5.1
See related: AllianceGenome:WB:WBGene00018786
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable double-stranded telomeric DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including body wall musculature; enteric muscle; mechanosensory neurons; somatic nervous system; and vulval muscle. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hmbx-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (989671..992178)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the conserved transcription factor hmbx-1, stabilizes AWC gene expression in adult animals through dosage-sensitive interactions with its transcriptional targets
Title: The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C54G6.4 (e-PCR)
- UniSTS:316437

STS1-244 (e-PCR)
- UniSTS:241736

F54A5.1 (e-PCR)
- UniSTS:318854

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox-containing protein 1

NP_001370599.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

989671..992178

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383445.2 → NP_001370599.1 Homeobox-containing protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TYT0

Conserved Domains (2) summary

cd00086
Location:216 → 290

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:6 → 184

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus