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    did-2 Charged multivesicular body protein 1b [ Caenorhabditis elegans ]

    Gene ID: 171801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    did-2
    Official Full Name
    Charged multivesicular body protein 1b
    Primary source
    WormBase:WBGene00017735
    Locus tag
    CELE_F23C8.6
    See related
    AllianceGenome:WB:WBGene00017735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Located in endosome membrane. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human CHMP1B (charged multivesicular body protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See did-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (2420834..2421816, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein Neighboring gene Electron transfer flavoprotein subunit beta Neighboring gene Tyrosine-protein kinase Neighboring gene non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESCRT-Dependent Cell Death in a Caenorhabditis elegans Model of the Lysosomal Storage Disorder Mucolipidosis Type IV. Huynh JM, et al. Genetics, 2016 Feb. PMID 26596346, Free PMC Article
    2. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    3. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. Frische EW, et al. EMBO J, 2007 Dec 12. PMID 17989692, Free PMC Article
    4. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Gao J, et al. PLoS Genet, 2015 Mar. PMID 25768301, Free PMC Article
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Charged multivesicular body protein 1b
    NP_490974.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2420834..2421816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058573.6 → NP_490974.1  Charged multivesicular body protein 1b [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXI3
      Conserved Domains (1) summary
      cl21588
      Location:16 → 181
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version

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