eak-7 MTOR-associated protein MEAK7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eak-7
Official Full Name: MTOR-associated protein MEAK7
Primary source: WormBase:WBGene00010671
Locus tag: CELE_K08E7.1
See related: AllianceGenome:WB:WBGene00010671
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Located in plasma membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and vulva. Orthologous to human MEAK7 (MTOR associated protein, eak-7 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eak-7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (12563775..12565983, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EAK-7 as a FoxO regulator and highlight the biological impact of a regulatory pathway that governs the activity of nuclear FoxO without altering its subcellular location.
Title: EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08E7.1 (e-PCR)
- UniSTS:307786

K08E7.3 (e-PCR)
- UniSTS:311479

K08E7.2 (e-PCR)
- UniSTS:321005

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MTOR-associated protein MEAK7

NP_502405.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12563775..12565983 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070004.7 → NP_502405.1 MTOR-associated protein MEAK7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502405.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21342

Conserved Domains (1) summary

smart00584
Location:177 → 344

TLDc; domain in TBC and LysM domain containing proteins