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    fcd-2 FANCD2 [ Caenorhabditis elegans ]

    Gene ID: 178418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fcd-2
    Official Full Name
    FANCD2
    Primary source
    WormBase:WBGene00012767
    Locus tag
    CELE_Y41E3.9
    See related
    AllianceGenome:WB:WBGene00012767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA polymerase binding activity. Involved in nucleotide-excision repair and regulation of DNA-templated DNA replication. Located in nucleus. Is expressed in germ line. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast cancer. Orthologous to human FANCD2 (FA complementation group D2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fcd-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (15025710..15037036)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ACB domain-containing protein;GOLD domain-containing protein;Golgi resident protein GCP60 Neighboring gene ncRNA Neighboring gene Glycine Rich Secreted Protein Neighboring gene putative elongation factor 1-beta/1-delta 2 Neighboring gene ncRNA Neighboring gene B30.2/SPRY domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental stage- and DNA damage-specific functions of C. elegans FANCD2. Lee KY, et al. Biochem Biophys Res Commun, 2007 Jan 12. PMID 17126808
    2. C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair. Collis SJ, et al. DNA Repair (Amst), 2006 Nov 8. PMID 16914393
    3. The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage. Dequen F, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 Aug. PMID 15979372
    4. In vivo analysis of FANCD2 recruitment at meiotic DNA breaks in Caenorhabditis elegans. Germoglio M, et al. Sci Rep, 2020 Jan 9. PMID 31919410, Free PMC Article
    5. Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans. Marchal L, et al. Mech Ageing Dev, 2021 Dec. PMID 34562508, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FCD-2 is required for maintaining histone methylation levels.
      Title: Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans.
    2. The FCD-2 gene, functional homolog of the human, FANCD2 has been identified and is associated with DNA repair.
      Title: C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair involved in meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in condensed chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FANCD2
    NP_001255848.1
    • Confirmed by transcript evidence
    NP_001255849.1
    • Confirmed by transcript evidence
    NP_001255850.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15025710..15037036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268919.3 → NP_001255848.1  FANCD2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2H4
      Conserved Domains (1) summary
      cl17018
      Location:142 → 1431
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

    2. NM_001268920.3 → NP_001255849.1  FANCD2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT99
      Conserved Domains (1) summary
      cl17018
      Location:523 → 843
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

    3. NM_001268921.3 → NP_001255850.1  FANCD2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCJ4
      Conserved Domains (1) summary
      cl17018
      Location:166 → 486
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2
    Nucleotide Protein
    Heading Accession and Version

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