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    mbr-1 Mblk-1-related factor 1 [ Caenorhabditis elegans ]

    Gene ID: 187937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mbr-1
    Official Full Name
    Mblk-1-related factor 1
    Primary source
    WormBase:WBGene00011315
    Locus tag
    CELE_T01C1.2
    See related
    AllianceGenome:WB:WBGene00011315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including AUA; intestine; nerve ring neurons; tail; and vulva. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor) and LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mbr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (10719548..10722054, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans. Hayashi Y, et al. Nat Neurosci, 2009 Aug. PMID 19561603
    2. A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans. Feng H, et al. Gene, 2012 Feb 15. PMID 22207033, Free PMC Article
    3. MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans. Kage E, et al. Curr Biol, 2005 Sep 6. PMID 16139210
    4. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Lakhina V, et al. Neuron, 2015 Jan 21. PMID 25611510, Free PMC Article
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MBR-1, a helix-turn-helix transcription factor, is required for pruning excessive neurites during larval stages.
      Title: MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mblk-1-related factor 1
    NP_509794.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10719548..10722054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077393.8 → NP_509794.2  Mblk-1-related factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509794.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGQ5
      Conserved Domains (1) summary
      pfam05225
      Location:347 → 388
      HTH_psq; helix-turn-helix, Psq domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGQ5.1

    Gene LinkOut

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