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    ncx-10 Sodium/calcium exchanger membrane region domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncx-10
    Official Full Name
    Sodium/calcium exchanger membrane region domain-containing protein
    Primary source
    WormBase:WBGene00003575
    Locus tag
    CELE_Y97E10B.7
    See related
    AllianceGenome:WB:WBGene00003575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Is expressed in pharyngeal muscle cell and terminal bulb. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncx-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (7930475..7933098, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism. Bode K, et al. Gene, 2022 Feb 5. PMID 34756961
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/calcium exchanger membrane region domain-containing protein
    NP_001256094.1
    • Partially confirmed by transcript evidence
    NP_001360010.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7930475..7933098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373058.1 → NP_001360010.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9P2J5
      Conserved Domains (2) summary
      PLN03151
      Location:5 → 454
      PLN03151; cation/calcium exchanger; Provisional
      pfam01699
      Location:375 → 542
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001269165.1 → NP_001256094.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965R5
      Conserved Domains (2) summary
      PLN03151
      Location:35 → 571
      PLN03151; cation/calcium exchanger; Provisional
      pfam01699
      Location:492 → 659
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein
    Heading Accession and Version

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