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    laat-1 Lysosomal amino acid transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 3565323, updated on 9-Dec-2024

    Summary

    Official Symbol
    laat-1
    Official Full Name
    Lysosomal amino acid transporter 1
    Primary source
    WormBase:WBGene00021546
    Locus tag
    CELE_Y43H11AL.2
    See related
    AllianceGenome:WB:WBGene00021546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables L-arginine transmembrane transporter activity and L-lysine transmembrane transporter activity. Involved in basic amino acid transport; intracellular amino acid homeostasis; and positive regulation of autophagy. Located in lysosomal membrane. Used to study lysosomal storage disease. Orthologous to several human genes including SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See laat-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (233139..237821, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UBX domain-containing protein 3 Neighboring gene ncRNA Neighboring gene ING domain-containing protein;PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nipped-B-like protein scc-2

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in lysosomal membrane PubMed 
    located_in lysosomal membrane  
    located_in lysosome  
    is_active_in membrane  
    located_in membrane  
    located_in organelle membrane PubMed 

    General protein information

    Preferred Names
    Lysosomal amino acid transporter 1
    NP_001300603.1
    • Confirmed by transcript evidence
    NP_493686.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      233139..237821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061285.7 → NP_493686.2  Lysosomal amino acid transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493686.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XZ6
      Conserved Domains (1) summary
      pfam04193
      Location:42 → 97
      PQ-loop; PQ loop repeat
    2. NM_001313674.3 → NP_001300603.1  Lysosomal amino acid transporter 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARR4
      Conserved Domains (1) summary
      pfam04193
      Location:113 → 171
      PQ-loop; PQ loop repeat
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