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    Y71H2AR.2 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y71H2AR.2
    Official Full Name
    Peptidase C1A papain C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00022189
    Locus tag
    CELE_Y71H2AR.2
    See related
    AllianceGenome:WB:WBGene00022189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in membrane. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy and pycnodysostosis. Orthologous to human CTSK (cathepsin K) and CTSS (cathepsin S). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y71H2AR.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (2839120..2840927, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Thioredoxin domain-containing protein 17 Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene CUB domain-containing protein Neighboring gene Conserved secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase C1A papain C-terminal domain-containing protein
    NP_001367938.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2839120..2840927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381789.1 → NP_001367938.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL26
      Conserved Domains (1) summary
      cd02248
      Location:84 → 290
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    Nucleotide Protein
    Heading Accession and Version

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