zoo-1 Tight junction protein ZO-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zoo-1
Official Full Name: Tight junction protein ZO-1
Primary source: WormBase:WBGene00013683
Locus tag: CELE_Y105E8A.26
See related: AllianceGenome:WB:WBGene00013683
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cell adhesion molecule binding activity. Involved in actin filament organization; embryo development; and embryonic morphogenesis. Located in adherens junction and bicellular tight junction. Is expressed in muscle cell. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to several human genes including TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zoo-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (14529529..14546870)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-259 (e-PCR)
- UniSTS:241752

Y105E8D.a (e-PCR)
- UniSTS:323838

Y105E8D.b (e-PCR)
- UniSTS:323839

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tight junction protein ZO-1

NP_001252376.1

Confirmed by transcript evidence

NP_001252377.1

Confirmed by transcript evidence

NP_001252378.1

Confirmed by transcript evidence

NP_001364648.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14529529..14546870

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001265447.4 → NP_001252376.1 Tight junction protein ZO-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252376.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I103

Conserved Domains (4) summary

cd11859
Location:420 → 487

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

cd00992
Location:46 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00791
Location:1033 → 1133

ZU5; ZU5 domain

cl17190
Location:539 → 690

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001377679.2 → NP_001364648.1 Tight junction protein ZO-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q56VX4

Conserved Domains (4) summary

cd11859
Location:420 → 487

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

cd00992
Location:46 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00791
Location:994 → 1094

ZU5; ZU5 domain

cl17190
Location:539 → 690

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001265448.4 → NP_001252377.1 Tight junction protein ZO-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252377.1

Status: REVIEWED

UniProtKB/TrEMBL

H1UBK9

Conserved Domains (4) summary

cd11859
Location:388 → 455

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

cd00992
Location:14 → 96

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00791
Location:1001 → 1099

ZU5; ZU5 domain

cl17190
Location:507 → 658

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001265449.3 → NP_001252378.1 Tight junction protein ZO-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252378.1

Status: REVIEWED

UniProtKB/TrEMBL

H1UBL0

Conserved Domains (4) summary

cd11859
Location:296 → 363

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

cd00992
Location:202 → 277

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00791
Location:909 → 1007

ZU5; ZU5 domain

cl17190
Location:415 → 566

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...