lpin-1 LNS2/PITP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lpin-1
Official Full Name: LNS2/PITP domain-containing protein
Primary source: WormBase:WBGene00010425
Locus tag: CELE_H37A05.1
See related: AllianceGenome:WB:WBGene00010425
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Involved in several processes, including lipid storage; nematode larval development; and nuclear membrane organization. Located in endoplasmic reticulum; nuclear envelope; and nucleoplasm. Is expressed in head neurons; hypodermis; intestine; and reproductive system. Used to study obesity. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to several human genes including LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lpin-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (13650262..13654129, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study examines LPIN-1(H37A05.1) effect on nuclear envelope(NE)dynamics; lpin-1 RNAi causes defects in NE breakdown, abnormal chromosome segregation & nuclear morphology
Title: Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope.
Lpin-1 (H37A05.1) was required for disassembly of the nuclear lamina during late nuclear enveloppe breakdown
Title: Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H37A05.1 (e-PCR)
- UniSTS:306957

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamin depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane reassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LNS2/PITP domain-containing protein

NP_506380.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13650262..13654129 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073979.7 → NP_506380.2 LNS2/PITP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506380.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9XXT5

Conserved Domains (2) summary

COG5083
Location:1 → 736

SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

pfam08235
Location:508 → 732

LNS2; LNS2 (Lipin/Ned1/Smp2)