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    max-2 Serine/threonine-protein kinase max-2;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 3565400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    max-2
    Official Full Name
    Serine/threonine-protein kinase max-2;non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00003144
    Locus tag
    CELE_Y38F1A.10
    See related
    AllianceGenome:WB:WBGene00003144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including gonad morphogenesis; inductive cell migration; and netrin-activated signaling pathway. Predicted to be located in dendrite and perikaryon. Predicted to be active in cytoplasm. Is expressed in neurons; pharynx; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See max-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (13014317..13025844, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ig-like domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Core Molecular Machinery Used for Engulfment of Apoptotic Cells Regulates the JNK Pathway Mediating Axon Regeneration in Caenorhabditis elegans. Pastuhov SI, et al. J Neurosci, 2016 Sep 14. PMID 27629720, Free PMC Article
    2. Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations. Peters EC, et al. G3 (Bethesda), 2013 Feb. PMID 23390595, Free PMC Article
    3. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. Ito TK, et al. PLoS One, 2014. PMID 25057989, Free PMC Article
    4. CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin. Quinn CC, et al. Curr Biol, 2008 Jun 3. PMID 18499456, Free PMC Article
    5. CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans. Tannoury H, et al. Dev Biol, 2010 May 1. PMID 20188721, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAX-2 functions downstream of the UNC-6/netrin receptor UNC-5 during axon repulsion and is an integral part of its signaling.
      Title: The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.
    2. results suggest that MAX-2 and MIG-2 play a crucial role in mediating the heavy metal stress response regulated by the KGB-1 pathway.
      Title: The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gonad morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inductive cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in netrin-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase max-2;non-specific serine/threonine protein kinase
    NP_001076635.1
    • Confirmed by transcript evidence
    NP_001076636.1
    • Confirmed by transcript evidence
    NP_001122655.1
    • Confirmed by transcript evidence
    NP_001254363.1
    • Confirmed by transcript evidence
    NP_001300485.1
    • Confirmed by transcript evidence
    NP_001300486.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13014317..13025844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083167.2 → NP_001076636.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGQ3
      Conserved Domains (2) summary
      smart00220
      Location:156 → 407
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06614
      Location:155 → 408
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase

    2. NM_001129183.4 → NP_001122655.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGQ3, G5EGS0, H2KMK1, Q9XWL8
      Conserved Domains (2) summary
      cd06614
      Location:375 → 628
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
      pfam00786
      Location:40 → 94
      PBD; P21-Rho-binding domain

    3. NM_001313556.2 → NP_001300485.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQV8
      Conserved Domains (2) summary
      smart00220
      Location:379 → 630
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06614
      Location:378 → 631
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase

    4. NM_001083166.5 → NP_001076635.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076635.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGQ3
      Conserved Domains (2) summary
      smart00220
      Location:328 → 579
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06614
      Location:327 → 580
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase

    5. NM_001313557.3 → NP_001300486.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUE7
      Conserved Domains (2) summary
      cd06614
      Location:330 → 583
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
      pfam00786
      Location:40 → 97
      PBD; P21-Rho-binding domain

    6. NM_001267434.3 → NP_001254363.1  Serine/threonine-protein kinase max-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGQ3
      Conserved Domains (2) summary
      smart00220
      Location:1 → 250
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06614
      Location:3 → 251
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGQ3.1

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