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    ntfc-1 Cytosolic purine 5'-nucleotidase [ Caenorhabditis elegans ]

    Gene ID: 180573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntfc-1
    Official Full Name
    Cytosolic purine 5'-nucleotidase
    Primary source
    WormBase:WBGene00022201
    Locus tag
    CELE_Y71H10B.1
    See related
    AllianceGenome:WB:WBGene00022201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-nucleotidase activity. Is expressed in several structures, including anal depressor muscle; hypodermis; pharynx; reproductive system; and tail. Used to study obesity. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to several human genes including NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntfc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (2834224..2840292, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Tetraspanin Neighboring gene ncRNA Neighboring gene Sperm-Specific family, class R Neighboring gene Serine/threonine-protein kinase kin-29 Neighboring gene Zinc finger protein tra-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes in human obesity loci are causal obesity genes in C. elegans. Ke W, et al. PLoS Genet, 2021 Sep. PMID 34492009, Free PMC Article
    2. Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo. van der Vaart A, et al. Sci Adv, 2020 May. PMID 32494730, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytosolic purine 5'-nucleotidase
    NP_001361936.1
    • Confirmed by transcript evidence
    NP_001379633.1
    • Confirmed by transcript evidence
    NP_508491.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2834224..2840292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076090.9 → NP_508491.1  Cytosolic purine 5'-nucleotidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508491.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95X21
      Conserved Domains (1) summary
      pfam05761
      Location:24 → 459
      5_nucleotid; 5' nucleotidase family

    2. NM_001392738.1 → NP_001379633.1  Cytosolic purine 5'-nucleotidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZC8
      Conserved Domains (1) summary
      pfam05761
      Location:21 → 456
      5_nucleotid; 5' nucleotidase family

    3. NM_001374980.2 → NP_001361936.1  Cytosolic purine 5'-nucleotidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MI3
      Conserved Domains (1) summary
      pfam05761
      Location:1 → 428
      5_nucleotid; 5' nucleotidase family
    Nucleotide Protein
    Heading Accession and Version

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