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    hyl-1 Ceramide synthase hyl-1;TLC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hyl-1
    Official Full Name
    Ceramide synthase hyl-1;TLC domain-containing protein
    Primary source
    WormBase:WBGene00002043
    Locus tag
    CELE_C09G4.1
    See related
    AllianceGenome:WB:WBGene00002043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Involved in regulation of locomotion. Located in axon. Is expressed in intestine; nervous system; and pharynx. Orthologous to several human genes including CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hyl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (8539123..8544412)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein;cGMP-dependent protein kinase Neighboring gene Neuropeptide receptor 22 Neighboring gene Rhodanese domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1. Tedesco P, et al. Age (Dordr), 2008 Mar. PMID 19424872, Free PMC Article
    2. Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Jazwinski SM. Ageing Res Rev, 2015 Sep. PMID 25555678, Free PMC Article
    3. Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans. Chan JP, et al. Front Genet, 2017. PMID 28983319, Free PMC Article
    4. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition. Zhu H, et al. J Biol Chem, 2024 Jun. PMID 38677510, Free PMC Article
    5. Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors. Chan JP, et al. J Neurosci, 2012 Dec 5. PMID 23223309, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ceramide synthase hyl-1;TLC domain-containing protein
    NP_001294030.1
    • Confirmed by transcript evidence
    NP_001368453.1
    • Confirmed by transcript evidence
    NP_501459.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8539123..8544412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307101.3 → NP_001294030.1  TLC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LPS5
      Conserved Domains (1) summary
      smart00724
      Location:94 → 305
      TLC; TRAM, LAG1 and CLN8 homology domains

    2. NM_069058.9 → NP_501459.1  Ceramide synthase hyl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ED45
      Conserved Domains (1) summary
      smart00724
      Location:90 → 301
      TLC; TRAM, LAG1 and CLN8 homology domains

    3. NM_001380373.1 → NP_001368453.1  TLC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LX61
      Conserved Domains (1) summary
      smart00724
      Location:87 → 298
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ED45.1

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