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    cav-1 Caveolin;Caveolin-1 [ Caenorhabditis elegans ]

    Gene ID: 177815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cav-1
    Official Full Name
    Caveolin;Caveolin-1
    Primary source
    WormBase:WBGene00000301
    Locus tag
    CELE_T13F2.8
    See related
    AllianceGenome:WB:WBGene00000301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable molecular adaptor activity. Involved in Ras protein signal transduction; meiotic cell cycle; and regulation of egg-laying behavior. Located in several cellular components, including cytoplasmic side of plasma membrane; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including germ cell; germ line; nervous system; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscle tissue disease (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cav-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (9772510..9773559)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Major sperm protein 78 Neighboring gene Small Nuclear RNA (snRNA) Associated protein Neighboring gene DUF4210 domain-containing protein Neighboring gene Serpentine Receptor, class E (Epsilon)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary analysis and molecular dissection of caveola biogenesis. Kirkham M, et al. J Cell Sci, 2008 Jun 15. PMID 18505796
    2. Caveolin, cholesterol and Ras signalling. Sternberg PW, et al. Nat Cell Biol, 1999 Jun. PMID 10559891
    3. Endogenous expression and localization of CAV-1::GFP in C. elegans. Sloan DE, et al. MicroPubl Biol, 2020 Sep 21. PMID 33005882, Free PMC Article
    4. Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes. Tang Z, et al. J Biol Chem, 1997 Jan 24. PMID 8999956
    5. Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity. Parker S, et al. Commun Integr Biol, 2009 Sep. PMID 19907693, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
      Title: CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
    2. These data link RABS-5 and VPS-45 ciliary functions to the processing of periciliary-derived endocytic vesicles and regulation of ciliary membrane homeostasis. Our findings also provide insight into the regulation of PKD-2 ciliary levels via integrated endosomal sorting and CAV-1-mediated endocytosis.
      Title: Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 regulate ciliary membrane and polycystin-2 homeostasis.
    3. The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.
      Title: Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in caveola assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in caveola assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in caveola TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft HDA PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Caveolin;Caveolin-1
    NP_001255421.1
    • Confirmed by transcript evidence
    NP_001255422.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9772510..9773559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268492.4 → NP_001255421.1  Caveolin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94051
      Conserved Domains (1) summary
      pfam01146
      Location:93 → 223
      Caveolin; Caveolin

    2. NM_001268493.3 → NP_001255422.1  Caveolin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2G6
      Conserved Domains (1) summary
      pfam01146
      Location:1 → 114
      Caveolin; Caveolin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94051.1

    Gene LinkOut

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