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    pign-1 GPI ethanolamine phosphate transferase 1 [ Caenorhabditis elegans ]

    Gene ID: 171881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pign-1
    Official Full Name
    GPI ethanolamine phosphate transferase 1
    Primary source
    WormBase:WBGene00021840
    Locus tag
    CELE_Y54E10BR.1
    See related
    AllianceGenome:WB:WBGene00021840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pign-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (3057694..3069410)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene DNA-directed RNA polymerase II subunit RPB7 Neighboring gene Transporter Neighboring gene C2H2-type domain-containing protein Neighboring gene Ensconsin Neighboring gene Actin-related protein 2/3 complex subunit 5 Neighboring gene Serine/threonine-protein kinase RIO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New allele of C. elegans gene pign-1, named as xyz11. Narimatsu T, et al. MicroPubl Biol, 2019 Jan 18. PMID 32550470, Free PMC Article
    2. PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis. Ihara S, et al. J Cell Sci, 2017 Feb 1. PMID 27980068
    3. The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans. Norris AD, et al. Neural Dev, 2009 Oct 2. PMID 19799769, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIGN-1/PIGN is required for quality control in Caenorhabditis elegans and in mammalian cells.
      Title: PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI ethanolamine phosphate transferase 1
    NP_001249296.1
    • Partially confirmed by transcript evidence
    NP_001249297.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3057694..3069410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001262368.4 → NP_001249297.1  GPI ethanolamine phosphate transferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3C5
      Conserved Domains (2) summary
      cd16020
      Location:42 → 320
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
      pfam04987
      Location:404 → 844
      PigN; Phosphatidylinositolglycan class N (PIG-N)

    2. NM_001262367.2 → NP_001249296.1  GPI ethanolamine phosphate transferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SNP0
      Conserved Domains (2) summary
      cd16020
      Location:42 → 320
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
      pfam04987
      Location:404 → 850
      PigN; Phosphatidylinositolglycan class N (PIG-N)
    Nucleotide Protein
    Heading Accession and Version

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