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    letm-1 Mitochondrial proton/calcium exchanger protein [ Caenorhabditis elegans ]

    Gene ID: 179854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    letm-1
    Official Full Name
    Mitochondrial proton/calcium exchanger protein
    Primary source
    WormBase:WBGene00010279
    Locus tag
    CELE_F58G11.1
    See related
    AllianceGenome:WB:WBGene00010279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed widely. Orthologous to several human genes including LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See letm-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (13661257..13664233)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene LNS2/PITP domain-containing protein Neighboring gene ncRNA Neighboring gene DEAD-box ATP-dependent RNA helicase rde-12 Neighboring gene HTH OST-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inverse correlation between expression of the Wolfs Hirschhorn candidate gene Letm1 and mitochondrial volume in C. elegans and in mammalian cells. Hasegawa A, et al. Hum Mol Genet, 2007 Sep 1. PMID 17606466
    2. Cross-species RNAi: selected Ascaris suum dsRNAs can sterilize Caenorhabditis elegans. Gao G, et al. Mol Biochem Parasitol, 2006 Mar. PMID 16388861
    3. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial proton/calcium exchanger protein
    NP_506381.1
    • Confirmed by transcript evidence
    NP_506382.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13661257..13664233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073981.8 → NP_506382.1  Mitochondrial proton/calcium exchanger protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVL7
      Conserved Domains (1) summary
      pfam07766
      Location:94 → 351
      LETM1; LETM1-like protein

    2. NM_073980.7 → NP_506381.1  Mitochondrial proton/calcium exchanger protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVM0
      Conserved Domains (1) summary
      pfam07766
      Location:94 → 351
      LETM1; LETM1-like protein
    Nucleotide Protein
    Heading Accession and Version

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