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    age-1 Phosphatidylinositol 3-kinase age-1 [ Caenorhabditis elegans ]

    Gene ID: 174762, updated on 9-Dec-2024

    Summary

    Official Symbol
    age-1
    Official Full Name
    Phosphatidylinositol 3-kinase age-1
    Primary source
    WormBase:WBGene00000090
    Locus tag
    CELE_B0334.8
    See related
    AllianceGenome:WB:WBGene00000090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Is expressed in anchor cell; hypodermis; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); primary immunodeficiency disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See age-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (11519328..11527054, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Reverse transcriptase domain-containing protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity  
    enables 1-phosphatidylinositol-3-kinase activity  
    enables 1-phosphatidylinositol-3-kinase activity PubMed 
    enables 1-phosphatidylinositol-3-kinase activity PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity  
    enables ATP binding  
    enables kinase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in cell migration  
    involved_in cellular response to salt PubMed 
    involved_in cellular response to salt PubMed 
    involved_in chemosensory behavior PubMed 
    involved_in chemotaxis PubMed 
    involved_in dauer entry PubMed 
    involved_in dauer larval development PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in learning or memory PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol phosphate biosynthetic process  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process  
    involved_in phosphatidylinositol-mediated signaling  
    involved_in regulation of chemotaxis PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction PubMed 
    involved_in reproductive process PubMed 
    involved_in response to cadmium ion PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in response to salt PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in non-motile cilium PubMed 
    part_of phosphatidylinositol 3-kinase complex  
    part_of phosphatidylinositol 3-kinase complex PubMed 
    part_of phosphatidylinositol 3-kinase complex PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Phosphatidylinositol 3-kinase age-1
    NP_001300488.1
    • Confirmed by transcript evidence
    NP_496462.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11519328..11527054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064061.6 → NP_496462.2  Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496462.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3ARF0, Q17482, Q94125
      Conserved Domains (5) summary
      cd08380
      Location:420 → 574
      C2_PI3K_like; C2 domain present in phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:98 → 177
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:241 → 360
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      smart00145
      Location:606 → 798
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cl21453
      Location:793 → 1181
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001313559.3 → NP_001300488.1  Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARF0
      Conserved Domains (1) summary
      cl21453
      Location:7 → 75
      PKc_like; Protein Kinases, catalytic domain
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