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    LARP1 La ribonucleoprotein 1, translational regulator [ Homo sapiens (human) ]

    Gene ID: 23367, updated on 10-Dec-2024

    Summary

    Official Symbol
    LARP1provided by HGNC
    Official Full Name
    La ribonucleoprotein 1, translational regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:29531
    See related
    Ensembl:ENSG00000155506 MIM:612059; AllianceGenome:HGNC:29531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LARP; Lar1; Lhp1
    Summary
    Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Located in TORC1 complex and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LARP1 in Genome Data Viewer
    Location:
    5q33.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (154682979..154817605)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (155216967..155351568)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154062539..154197165)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:153962321-153962904 Neighboring gene CIR1P1-LARP1 intergenic CAGE-defined high expression enhancer Neighboring gene CIR1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:153983238-153983756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:153983757-153984274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:153990742-153991511 Neighboring gene microRNA 3141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:154026765-154027427 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154070395-154071038 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:154076347-154076858 Neighboring gene microRNA 1303 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154091948-154092494 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83490 Neighboring gene RNA, 7SL, cytoplasmic 803, pseudogene Neighboring gene ribosomal protein L21 pseudogene 57 Neighboring gene uncharacterized LOC112267936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16553 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:154155175-154155753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:154161545-154162171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23487 Neighboring gene Sharpr-MPRA regulatory region 2591 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154236981-154237482 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154237483-154237986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:154237987-154238489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:154238993-154239495 Neighboring gene CCR4-NOT transcription complex subunit 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated La ribonucleoprotein domain family, member 1 (LARP1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with La ribonucleoprotein domain family, member 1 (LARP1) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0731, MGC19556

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of TORC1 complex PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule PubMed 
    is_active_in cytosol  
    located_in cytosol  
    located_in membrane PubMed 

    General protein information

    Preferred Names
    la-related protein 1
    Names
    La ribonucleoprotein domain family member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367713.1 → NP_001354642.1  la-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
      Consensus CDS
      CCDS93807.1
      UniProtKB/TrEMBL
      A0A8I5KWU3
      Related
      ENSP00000509794.1, ENST00000685946.1
    2. NM_001367714.1 → NP_001354643.1  la-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
      Consensus CDS
      CCDS93807.1
      UniProtKB/TrEMBL
      A0A8I5KWU3
      Related
      ENSP00000508743.1, ENST00000690816.1
    3. NM_001367715.1 → NP_001354644.1  la-related protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    4. NM_001367716.1 → NP_001354645.1  la-related protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
      Consensus CDS
      CCDS93806.1
      UniProtKB/TrEMBL
      A0A8I5KSP1
      Related
      ENSP00000508958.1, ENST00000687700.1
    5. NM_001367717.1 → NP_001354646.1  la-related protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    6. NM_001367718.1 → NP_001354647.1  la-related protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC112169
    7. NM_001367719.1 → NP_001354648.1  la-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112169
      Consensus CDS
      CCDS93807.1
      UniProtKB/TrEMBL
      A0A8I5KWU3
    8. NM_015315.6 → NP_056130.2  la-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056130.2

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
      Consensus CDS
      CCDS4328.1
      UniProtKB/Swiss-Prot
      Q6PKG0
      Related
      ENSP00000336721.4, ENST00000336314.9
      Conserved Domains (4) summary
      smart00684
      Location:849 → 887
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:327 → 399
      LARP_1; La RNA-binding domain of La-related protein 1
      cl25751
      Location:123 → 535
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:11 → 251
      Atrophin-1; Atrophin-1 family
    9. NM_033551.3 → NP_291029.2  la-related protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112169
      UniProtKB/Swiss-Prot
      O94836, Q6PKG0, Q8N4M2, Q8NB73, Q9UFD7
      Related
      ENSP00000428589.2, ENST00000518297.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      154682979..154817605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417041.1 → XP_047272997.1  la-related protein 1 isoform X3

    2. XM_047417045.1 → XP_047273001.1  la-related protein 1 isoform X9

    3. XM_047417040.1 → XP_047272996.1  la-related protein 1 isoform X3

    4. XM_047417042.1 → XP_047272998.1  la-related protein 1 isoform X4

    5. XM_047417044.1 → XP_047273000.1  la-related protein 1 isoform X7

    6. XM_047417043.1 → XP_047272999.1  la-related protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5KSP1
    7. XM_011537614.2 → XP_011535916.1  la-related protein 1 isoform X1

      Conserved Domains (3) summary
      smart00684
      Location:900 → 938
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:378 → 450
      LARP_1; La RNA-binding domain of La-related protein 1
      COG5193
      Location:177 → 529
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    8. XM_011537615.2 → XP_011535917.1  la-related protein 1 isoform X2

      Conserved Domains (3) summary
      smart00684
      Location:859 → 897
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:337 → 409
      LARP_1; La RNA-binding domain of La-related protein 1
      COG5193
      Location:211 → 488
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    9. XM_005268408.4 → XP_005268465.1  la-related protein 1 isoform X8

      See identical proteins and their annotated locations for XP_005268465.1

      UniProtKB/TrEMBL
      A0A8I5KWU3
      Conserved Domains (2) summary
      smart00684
      Location:721 → 759
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:199 → 271
      LARP_1; La RNA-binding domain of La-related protein 1
    10. XM_011537617.2 → XP_011535919.1  la-related protein 1 isoform X5

      Conserved Domains (2) summary
      smart00684
      Location:791 → 829
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:269 → 341
      LARP_1; La RNA-binding domain of La-related protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      155216967..155351568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352239.1 → XP_054208214.1  la-related protein 1 isoform X3

    2. XM_054352244.1 → XP_054208219.1  la-related protein 1 isoform X9

    3. XM_054352238.1 → XP_054208213.1  la-related protein 1 isoform X3

    4. XM_054352240.1 → XP_054208215.1  la-related protein 1 isoform X4

    5. XM_054352243.1 → XP_054208218.1  la-related protein 1 isoform X7

    6. XM_054352242.1 → XP_054208217.1  la-related protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5KSP1
    7. XM_054352236.1 → XP_054208211.1  la-related protein 1 isoform X1

    8. XM_054352237.1 → XP_054208212.1  la-related protein 1 isoform X2

    9. XM_054352241.1 → XP_054208216.1  la-related protein 1 isoform X5

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