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    MIF4GD MIF4G domain containing [ Homo sapiens (human) ]

    Gene ID: 57409, updated on 10-Dec-2024

    Summary

    Official Symbol
    MIF4GDprovided by HGNC
    Official Full Name
    MIF4G domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:24030
    See related
    Ensembl:ENSG00000125457 MIM:612072; AllianceGenome:HGNC:24030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIFD; AD023; SLIP1
    Summary
    This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in lymph node (RPKM 9.4), bone marrow (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MIF4GD in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75266228..75271292, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76158321..76163378, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73262309..73267373, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73201514-73202447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73203873-73204440 Neighboring gene nucleoporin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73220785-73221286 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73221550-73222749 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73230746-73230909 Neighboring gene Sharpr-MPRA regulatory region 15557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12738 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12740 Neighboring gene Sharpr-MPRA regulatory region 8279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12741 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73257869-73258746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8960 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73268227-73269014 Neighboring gene MIF4GD divergent transcript Neighboring gene solute carrier family 25 member 19 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:73284659-73285160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8963 Neighboring gene uncharacterized LOC124904059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12750

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC45027

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding  
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables translation activator activity  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol  
    part_of histone mRNA stem-loop binding complex PubMed 
    located_in nucleolus  

    General protein information

    Preferred Names
    MIF4G domain-containing protein
    Names
    SLBP (stem loop binding protein)-interacting protein 1
    SLBP-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242498.2NP_001229427.1  MIF4G domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001229427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 6, encodes the longest isoform (1).
      Source sequence(s)
      AC022211, AK300711, BC033759, BI752882
      Consensus CDS
      CCDS58598.1
      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Related
      ENSP00000462459.1, ENST00000579297.5
      Conserved Domains (1) summary
      cl02652
      Location:75220
      MIF4G; MIF4G domain
    2. NM_001242500.1NP_001229429.1  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001229429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform (2).
      Source sequence(s)
      AC022211, BC033759, BU190758
      Consensus CDS
      CCDS11719.1
      UniProtKB/TrEMBL
      A0A0S2Z5T5
      Conserved Domains (1) summary
      cl02652
      Location:68213
      MIF4G; MIF4G domain
    3. NM_001242501.1NP_001229430.1  MIF4G domain-containing protein isoform 4

      See identical proteins and their annotated locations for NP_001229430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 7-10, encodes isoform (4).
      Source sequence(s)
      BC033759, CA488406
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Related
      ENSP00000484245.1, ENST00000618645.5
      Conserved Domains (1) summary
      cl02652
      Location:8179
      MIF4G; MIF4G domain
    4. NM_001363806.2NP_001350735.1  MIF4G domain-containing protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS92390.1
      UniProtKB/TrEMBL
      J3KSB8
      Related
      ENSP00000462412.1, ENST00000580571.5
    5. NM_001365751.1NP_001352680.1  MIF4G domain-containing protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 1, encodes the longest isoform (1).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS58598.1
      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Conserved Domains (1) summary
      cl02652
      Location:75220
      MIF4G; MIF4G domain
    6. NM_001365752.1NP_001352681.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 4 and 8-10, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Related
      ENSP00000464448.1, ENST00000580717.5
      Conserved Domains (1) summary
      cl02652
      Location:8179
      MIF4G; MIF4G domain
    7. NM_001365753.1NP_001352682.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 4, 7, 9, and 10, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Conserved Domains (1) summary
      cl02652
      Location:8179
      MIF4G; MIF4G domain
    8. NM_001365754.1NP_001352683.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 4, 7, 8, and 10, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Conserved Domains (1) summary
      cl02652
      Location:8179
      MIF4G; MIF4G domain
    9. NM_001365755.1NP_001352684.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 4 and 7-9, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Conserved Domains (1) summary
      cl02652
      Location:8179
      MIF4G; MIF4G domain
    10. NM_001370592.1NP_001357521.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022211, AF225422, BP308696
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Related
      ENSP00000321625.8, ENST00000325102.13
      Conserved Domains (1) summary
      cl02652
      Location:8179
      MIF4G; MIF4G domain
    11. NM_001411093.1NP_001398022.1  MIF4G domain-containing protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS92391.1
      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6
    12. NM_020679.4NP_065730.2  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_065730.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform (2).
      Source sequence(s)
      AC022211, BC033759, BI752882, BX404175
      Consensus CDS
      CCDS11719.1
      UniProtKB/TrEMBL
      A0A0S2Z5T5
      Related
      ENSP00000245551.5, ENST00000245551.9
      Conserved Domains (1) summary
      cl02652
      Location:68213
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75266228..75271292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436457.1XP_047292413.1  MIF4G domain-containing protein isoform X6

    2. XM_047436452.1XP_047292408.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6
      Related
      ENSP00000463579.1, ENST00000579119.5
    3. XM_047436454.1XP_047292410.1  MIF4G domain-containing protein isoform X9

    4. XM_047436448.1XP_047292404.1  MIF4G domain-containing protein isoform X2

    5. XM_047436455.1XP_047292411.1  MIF4G domain-containing protein isoform X5

    6. XM_047436444.1XP_047292400.1  MIF4G domain-containing protein isoform X1

    7. XM_047436458.1XP_047292414.1  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8
    8. XM_047436456.1XP_047292412.1  MIF4G domain-containing protein isoform X10

    9. XM_047436450.1XP_047292406.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Related
      ENSP00000463334.1, ENST00000577542.5
    10. XM_047436445.1XP_047292401.1  MIF4G domain-containing protein isoform X1

    11. XM_047436447.1XP_047292403.1  MIF4G domain-containing protein isoform X1

    12. XM_011525055.3XP_011523357.2  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8
    13. XM_047436449.1XP_047292405.1  MIF4G domain-containing protein isoform X6

    14. XM_047436443.1XP_047292399.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6
    15. XM_011525052.3XP_011523354.2  MIF4G domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5T5
    16. XM_047436442.1XP_047292398.1  MIF4G domain-containing protein isoform X2

    17. XM_011525054.3XP_011523356.2  MIF4G domain-containing protein isoform X5

    18. XM_047436441.1XP_047292397.1  MIF4G domain-containing protein isoform X1

    19. XM_047436451.1XP_047292407.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Related
      ENSP00000462655.2, ENST00000579194.6
    20. XM_047436446.1XP_047292402.1  MIF4G domain-containing protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76158321..76163378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316743.1XP_054172718.1  MIF4G domain-containing protein isoform X6

    2. XM_054316738.1XP_054172713.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6
    3. XM_054316740.1XP_054172715.1  MIF4G domain-containing protein isoform X9

    4. XM_054316733.1XP_054172708.1  MIF4G domain-containing protein isoform X2

    5. XM_054316741.1XP_054172716.1  MIF4G domain-containing protein isoform X5

    6. XM_054316729.1XP_054172704.1  MIF4G domain-containing protein isoform X1

    7. XM_054316744.1XP_054172719.1  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8
    8. XM_054316742.1XP_054172717.1  MIF4G domain-containing protein isoform X10

    9. XM_054316736.1XP_054172711.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7
    10. XM_054316730.1XP_054172705.1  MIF4G domain-containing protein isoform X1

    11. XM_054316732.1XP_054172707.1  MIF4G domain-containing protein isoform X1

    12. XM_054316739.1XP_054172714.1  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8
    13. XM_054316735.1XP_054172710.1  MIF4G domain-containing protein isoform X6

    14. XM_054316728.1XP_054172703.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6
    15. XM_054316727.1XP_054172702.1  MIF4G domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5T5
    16. XM_054316726.1XP_054172701.1  MIF4G domain-containing protein isoform X2

    17. XM_054316734.1XP_054172709.1  MIF4G domain-containing protein isoform X5

    18. XM_054316725.1XP_054172700.1  MIF4G domain-containing protein isoform X1

    19. XM_054316737.1XP_054172712.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7
    20. XM_054316731.1XP_054172706.1  MIF4G domain-containing protein isoform X1

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