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    BDNF-AS BDNF antisense RNA [ Homo sapiens (human) ]

    Gene ID: 497258, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BDNF-ASprovided by HGNC
    Official Full Name
    BDNF antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:20608
    See related
    Ensembl:ENSG00000245573 MIM:611468; AllianceGenome:HGNC:20608
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BDNF; BDNFAS; BDNFOS; BDNF-AS1; ANTI-BDNF; NCRNA00049
    Expression
    Ubiquitous expression in brain (RPKM 3.5), thyroid (RPKM 1.9) and 23 other tissues See more
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    Genomic context

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    See BDNF-AS in Genome Data Viewer
    Location:
    11p14.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (27506852..27698171)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (27647322..27838600)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27528399..27719718)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:27527877-27529076 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component Neighboring gene RNA, 5S ribosomal pseudogene 339 Neighboring gene microRNA 8087 Neighboring gene ribosomal protein S25 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 104 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:27650686-27651472 Neighboring gene long intergenic non-protein coding RNA 678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27653431-27654320 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27655211-27656100 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:27656101-27656990 Neighboring gene Sharpr-MPRA regulatory region 8127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27708921-27709828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27709829-27710734 Neighboring gene brain derived neurotrophic factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:27743527-27744035 Neighboring gene uncharacterized LOC124902652 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27762065-27762756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27817576-27818442 Neighboring gene CBX3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer's disease. Ding Y, et al. Arch Gerontol Geriatr, 2022 Mar-Apr. PMID 34990931
    2. Long noncoding RNA BDNF-AS is associated with clinical outcomes and has functional role in human prostate cancer. Li W, et al. Biomed Pharmacother, 2018 Jun. PMID 29710528
    3. Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism. Marcos-Pasero H, et al. Clin Nutr, 2019 Dec. PMID 30501916
    4. LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma. Huang Q, et al. Biosci Rep, 2018 Dec 21. PMID 30352834, Free PMC Article
    5. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Liu QR, et al. Am J Med Genet B Neuropsychiatr Genet, 2005 Apr 5. PMID 15666411

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer's disease.
      Title: LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer's disease.
    2. Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.
      Title: Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.
    3. Blood and tissue levels of lncRNAs in periodontitis.
      Title: Blood and tissue levels of lncRNAs in periodontitis.
    4. Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism.
      Title: Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism.
    5. WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors
      Title: In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors.
    6. These results provide evidence on polymorphism of BDNF / BDNFOS gene associated with Lumbar disc herniation risk in Chinese Han population.
      Title: Associations between Variants in BDNF/BDNFOS Gene and Lumbar Disc Herniation Risk among Han Chinese People.
    7. effect of lncRNA BDNF-AS in colorectal cancer (CRC) and revealed that lncRNA BDNF-AS expression is negatively correlated with the aggressive biological behaviour of CRC; further investigation demonstrated that lncRNA BDNF-AS functioned as a tumour suppressor in CRC progression by suppressing GSK-3beta expression through binding to EZH2 and H3K27me3 with the GSK-3beta promoter, shedding light on the diagnosis and therap...
      Title: LncRNA BDNF-AS suppresses colorectal cancer cell proliferation and migration by epigenetically repressing GSK-3β expression.
    8. The multivariate analysis suggested low expression of BDNF-AS was an independent unfavorable prognostic factor for overall survival in osteosarcoma patients
      Title: LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma.
    9. Upregulation of BDNF-AS is associated with a significant decrease in BDNF expression and increased recruitment of EZH2. The results suggest an important role for BDNF-AS in the regulation of synaptic plasticity via epigenetic reprogramming in the amygdala of alcohol use disorders subjects who began drinking during adolescence.
      Title: The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders.
    10. Downregulated BDNF-AS in prostate cancer patients could be a potential prognostic biomarker for predicating poor prognosis and survival.
      Title: Long noncoding RNA BDNF-AS is associated with clinical outcomes and has functional role in human prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study identifies KCNMA1 contributing to human obesity.
    EBI GWAS Catalog
    Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
    EBI GWAS Catalog
    Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • BDNF antisense RNA (non-protein coding)
    • BDNF antisense RNA 1 (non-protein coding)
    • BDNF opposite strand (non-protein coding)
    • brain-derived neurotrophic factor opposite strand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002832.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (BT2B) represents the longest transcript.
      Source sequence(s)
      AC100771, AC104563, KF459669
      Related
      ENST00000499008.8

    2. NR_033312.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (BT1C) lacks an alternate exon and uses an alternate 3' splice pattern, compared to variant BT2B.
      Source sequence(s)
      AC100771, AC104563, KF459669
      Related
      ENST00000499568.3

    3. NR_033313.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (BT1A) lacks an alternate exon and uses an alternate 3' splice pattern, compared to variant BT2B.
      Source sequence(s)
      AC100771, AC104563, KF459669
      Related
      ENST00000502161.7

    4. NR_033314.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (BT2A) lacks an alternate exon, compared to variant BT2B.
      Source sequence(s)
      AC100771, AC104563, KF459669
      Related
      ENST00000651193.1

    5. NR_033315.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (BT1B) lacks two alternate exons and uses an alternate 3' splice pattern, compared to variant BT2B.
      Source sequence(s)
      AC100771, AC104563, KF459669
      Related
      ENST00000500662.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      27506852..27698171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      27647322..27838600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials