SHB SH2 domain containing adaptor protein B [Homo sapiens (human)] - Gene

Summary

Official Symbol: SHBprovided by HGNC
Official Full Name: SH2 domain containing adaptor protein Bprovided by HGNC
Primary source: HGNC:HGNC:10838
See related: Ensembl:ENSG00000107338 MIM:600314; AllianceGenome:HGNC:10838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: bA3J10.2
Summary: Enables phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p13.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (37915898..38069227, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (37939809..38093156, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (37915895..38069224, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2.
Title: The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2.
This article provides a resource for the available molecular tools that can be used in future research on Shb
Title: Evaluation and validation of commercial antibodies for the detection of Shb.
It is concluded that tumor SHB gene expression relates to acute myeloid leukemia survival
Title: Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia.
SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review]
Title: The role of the Src Homology-2 domain containing protein B (SHB) in β cells.
It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 and insulin in EBs and that such cells can be separated by FACS.
Title: SHB and angiogenic factors promote ES cell differentiation to insulin-producing cells.
Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF-induced neurite outgrowth.
Title: Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.
SHB links IL2 receptor for signal transduction and mediates apoptosis
Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.
SH2-Bbeta is a Rac-binding protein that regulates cell motility
Title: SH2-Bbeta is a Rac-binding protein that regulates cell motility.
Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells (SLP-76)
Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Voxelwise genome-wide association study (vGWAS). EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:594944 (e-PCR)
- UniSTS:158012

SHGC-12007 (e-PCR)
- UniSTS:43077

RH12398 (e-PCR)
- UniSTS:53591

SHGC-149857 (e-PCR)
- UniSTS:184928

STS-X75342 (e-PCR)
- UniSTS:8806

SHB_8624 (e-PCR)
- UniSTS:467884

SHGC-146997 (e-PCR)
- UniSTS:172728

D9S952 (e-PCR)
- UniSTS:33222

WI-19223 (e-PCR)
- UniSTS:38867

Potential readthrough

Included genes: EXOSC3, SLC25A51, TOMM5

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphotyrosine residue binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH2 domain-containing adapter protein B

Names: SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); Src homology 2 domain containing adaptor protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.